4-(2-hydroxyphenylhydrazono)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one | 18921-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-hydroxyphenylhydrazono)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
• 英文别名: 1-phenyl-3-methyl-4-(2-hydroxyphenylhydrazo)-5-pyrazolone；5-methyl-2-phenyl-2H-pyrazole-3,4-dione 4-[(2-hydroxy-phenyl)-hydrazone]；5-methyl-2-phenyl-2H-pyrazole-3,4-dione-4-((Z)-2-hydroxy-phenylhydrazone)；5-Methyl-2-phenyl-2H-pyrazol-3,4-dion-4-((Z)-2-hydroxy-phenylhydrazon)
• CAS: 18921-85-2
• 化学式: C₁₆H₁₄N₄O₂
• 分子量: 294.313
• InChiKey: ISARRSHHZPBZFI-SDXDJHTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.58
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.29
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-氨基苯酚 、 依达拉奉 在 sodium acetate 作用下， 生成 4-(2-hydroxyphenylhydrazono)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
  参考文献：
  名称：

  El-Maraghy; Salib; Stefan, Journal of the Indian Chemical Society, 1990, vol. 67, # 12, p. 988 - 991

  摘要：

  DOI：

文献信息

• Molecular design of new magnetically active copper complexes with heteroaromatic schiff bases and azo compounds
  作者：A. S. Burlov、A. I. Uraev、V. N. Ikorskii、S. A. Nikolaevskii、Yu. V. Koshchienko、I. S. Vasil’chenko、D. A. Garnovskii、V. G. Vlasenko、Ya. V. Zubavichus、L. N. Divaeva、G. S. Borodkin、A. D. Garnovskii

  DOI：10.1134/s1070363208060224

  日期：2008.6

  Copper chelates with tridentate ligands containing pyridine or pyrazole ring at the azomethine or azo fragment were synthesized by chemical electrochemical methods, and their structure was characterized by the EXAFS spectra. Thermal rnagnetochemical analysis of the complexes revealed anti ferromagnetic exchange interaction in all complexes. The exchange interaction parameter of the complex containing an N-tosylamino C7 C oroup in the ortho position with respect to the azomethine aroup is much lesser than that of the corresponding complex having an oxygen atom in the same position. The copper chelate derived from azopyrazole ligand C! shows low-temperature ferromagnetic phase transition.
• El-Maraghy, S. B.; Salib, K. A. R.; El-Inany, G. A., Journal of the Indian Chemical Society, 1988, vol. 65, p. 389 - 390
  作者：El-Maraghy, S. B.、Salib, K. A. R.、El-Inany, G. A.、Stefan, S. L.

  DOI：——

  日期：——
• An electronic spectral study of the coupled effect on the tautomeric equilibria of some α-hydroxy azo compounds
  作者：Z.A. Ahmed、F.M. Arta、M.A. Abd Alla、M.E. Abd El-Monem、S.A. Metwally

  DOI：10.1016/0584-8539(89)80254-5

  日期：1989.1
• ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Skaar Eric

  公开号：US20100004324A1

  公开（公告）日：2010-01-07

  In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8263642B2
  申请人：——

  公开号：US8263642B2

  公开（公告）日：2012-09-11