N-hydroxy-3-(4-{(R)-1-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-pyrrolidin-2-yl}-phenyl)-propionamide | 1189155-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-hydroxy-3-(4-{(R)-1-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-pyrrolidin-2-yl}-phenyl)-propionamide
• 英文别名: N-hydroxy-3-[4-[(2R)-1-[2-(1,3,5-trimethylpyrazol-4-yl)ethyl]pyrrolidin-2-yl]phenyl]propanamide
• CAS: 1189155-70-1
• 化学式: C₂₁H₃₀N₄O₂
• 分子量: 370.495
• InChiKey: LPUGCIYGAYAQSE-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B
  申请人：SHULTZ Michael

  公开号：US20090247547A1

  公开（公告）日：2009-10-01

  The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R 1 , R 2 , R 3 , Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.

  目前的教导与化合物I的公式有关：及其药用盐、水合物、酯和前药，其中R1、R2、R3、Y、Z和如本文所定义的。目前的教导还提供了制备公式I化合物的方法以及使用公式I化合物治疗、抑制或预防完全或部分由去乙酰酶介导的病理状况或紊乱的方法。
• Hydroxamate-based inhibitors of deacetylases b
  申请人：Novartis AG

  公开号：EP2628726A1

  公开（公告）日：2013-08-21

  The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.

  本教导涉及式 I 的化合物： 及其药学上可接受的盐、水合物、酯和原药，其中 R1、R2、R3、Y、Z 和如本文所定义。 本教导还提供了制备式 I 化合物的方法和使用式 I 化合物治疗、抑制或预防全部或部分由去乙酰化酶介导的病理状况或紊乱的方法。
• US7943652B2
  申请人：——

  公开号：US7943652B2

  公开（公告）日：2011-05-17
• US8349883B2
  申请人：——

  公开号：US8349883B2

  公开（公告）日：2013-01-08
• [EN] HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B<br/>[FR] INHIBITEURS DE DÉSACÉTYLASES B À BASE D'HYDROXAMATE
  申请人：NOVARTIS AG

  公开号：WO2009118305A1

  公开（公告）日：2009-10-01

  The present teachings relate to compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and (A) are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of using compounds of Formula (I) in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.