2,2-Difluoro-N-[(1S,5R,6R)-3-[5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]cyclopropanecarboxamide | 1883302-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,2-Difluoro-N-[(1S,5R,6R)-3-[5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]cyclopropanecarboxamide
• CAS: 1883302-72-4
• 化学式: C₁₈H₂₀F₃N₇O
• 分子量: 407.39
• InChiKey: VFTQZQGHFFDMQS-WUIIMLTRSA-N

物化性质

• 密度：
  1.69±0.1 g/cm³ (Predicted,Temp: 20 °C; Press: 760 Torr)
• pKa：
  14.27±0.40 (Predicted,Most Acidic Temp: 25 °C)

反应信息

• 作为反应物：
  描述：

  2,2-Difluoro-N-[(1S,5R,6R)-3-[5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]cyclopropanecarboxamide 生成 (1R)-2,2-difluoro-N-[(1S,5R,6R)-3-{5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]cyclopropanecarboxamide 、 (1S)-2,2-difluoro-N-[(1S,5R,6R)-3-{5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]cyclopropanecarboxamide
  参考文献：
  名称：

  [EN] AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS
  [FR] COMPOSÉS D'AMINOPYRIMIDINYLE EN TANT QU'INHIBITEURS DE JAK

  摘要：

  A compound compound having the structure or a pharmaceutic acceptable salt thereof: Formula (I). Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.

  公开号：

  WO2016027195A1