3-Methyl-2-oxo-4-(thiophen-2-yl)but-3-enoic acid | 920972-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 3-Methyl-2-oxo-4-(thiophen-2-yl)but-3-enoic acid
• 英文别名: 3-methyl-2-oxo-4-thiophen-2-ylbut-3-enoic acid
• CAS: 920972-81-2
• 化学式: C₉H₈O₃S
• 分子量: 196.22
• InChiKey: QUGJVAZITQKDLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  335.5±34.0 °C(Predicted)
• 密度：
  1.358±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  82.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Active substance combination for the treatment of diabetes
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946778A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, used to treat diabetes, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，用于治疗糖尿病，包括该活性物质组合的药物、包括该活性物质组合的制药配方以及利用该活性物质组合制造药物的用途。
• Substituted pyrazoline for preventing weight gain
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1946777A1

  公开（公告）日：2008-07-23

  The present invention relates to an active substance combination comprising at least one substituted pyrazoline compound and at least one drug, known to produce weight-gain as a side effect, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种活性物质组合，包括至少一种取代吡唑啉化合物和至少一种药物，该药物以体重增加作为副作用而知名，包括所述活性物质组合的药物、包括所述活性物质组合的药物制剂、以及利用所述活性物质组合制造药物。
• 4-Substituted Pyrazoline Compounds, their Preparation and Use as Medicaments
  申请人：TORRENS Antoni

  公开号：US20070073056A1

  公开（公告）日：2007-03-29

  The present invention relates to 4-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及4-取代吡唑啉化合物，其制备方法，包含这些化合物的药物以及它们用于制备用于治疗人类和动物的药物的用途。
• 4,5-DIHYDR0-1H-PYRAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1917247A1

  公开（公告）日：2008-05-07
• [EN] 4,5-DIHYDR0-1H-PYRAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS<br/>[FR] DERIVES DE 4, 5-DIHYDR0-1H-PYRAZOLE, PREPARATION ET UTILISATION DE CEUX-CI COMME MEDICAMENTS
  申请人：ESTEVE LABOR DR

  公开号：WO2007009689A1

  公开（公告）日：2007-01-25

  [EN] The present invention relates to 4-substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
  [FR] L'invention concerne des composés de pyrazoline 4 substituée de formule I, des procédés de préparation de ceux-ci, des médicaments comprenant ces composés, ainsi que l'utilisation de ceux-ci dans la préparation d'un médicament destiné au traitement d'êtres humains et d'animaux.