(3-Fluoromethyl-phenyl)-methanol | 96258-75-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Fluoromethyl-phenyl)-methanol
• 英文别名: (3-(Fluoromethyl)phenyl)methanol；[3-(fluoromethyl)phenyl]methanol
• CAS: 96258-75-2
• 化学式: C₈H₉FO
• 分子量: 140.157
• InChiKey: HVWLSFGSKLGRHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲基磺酰氯 、 (3-Fluoromethyl-phenyl)-methanol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Methanesulfonic acid 3-fluoromethyl-benzyl ester
  参考文献：
  名称：

  Stabilization demands of diethyl phosphonate substituted carbocations as revealed by substituent effects

  摘要：

  DOI：

  10.1021/jo00212a033

文献信息

• Process for producing aromatic aldehyde
  申请人：Kawazoe Kentaro

  公开号：US20070004934A1

  公开（公告）日：2007-01-04

  A process for producing an aromatic aldehyde compound represented by a general formula (3): (wherein R′ and n are as defined below), which comprises reacting a benzyl compound represented by a general formula (1): (wherein R may represents hydrogen atom, n represents an integer of 1 to 6, and R′ may be the same or different and represent a hydrogen atom or an alkyl gorup, an alkyl group or a phenyl group which may have a substituent) with an oxy-compound of bromine represented by the formula (2): MBrO m (2) (wherein M represents a hydrogen atom or a metal atom, and m represents an integer of 1 to 3) in the presence of an acid catalyst. According to this method, an aromatic aldehyde compound can be produced in high selectivity by a simple operation without using an expensive catalyst or transition metal.

  一种制备通式（3）所表示的芳香醛化合物的方法，包括将通式（1）所表示的苄基化合物（其中R可能代表氢原子，n表示1至6的整数，R'可以相同或不同，代表氢原子或具有取代基的烷基、苯基或烷基苯基）与通式（2）所表示的溴氧化物反应（其中M代表氢原子或金属原子，m表示1至3的整数），在酸催化剂的存在下进行。根据该方法，可以通过简单的操作，在不使用昂贵的催化剂或过渡金属的情况下高选择性地制备芳香醛化合物。
• PROCESS FOR PRODUCING AROMATIC ALDEHYDE
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1661877A1

  公开（公告）日：2006-05-31

  A process for producing an aromatic aldehyde compound represented by a general formula (3): (wherein R' and n are as defined below), which comprises reacting a benzyl compound represented by a general formula (1): (wherein R may represents hydrogen atom, n represents an integer of 1 to 6, and R' may be the same or different and represent a hydrogen atom or an alkyl gorup, an alkyl group or a phenyl group which may have a substituent) with an oxy-compound of bromine represented by the formula (2):         MBrOm     (2) (wherein M represents a hydrogen atom or a metal atom, and m represents an integer of 1 to 3) in the presence of an acid catalyst. According to this method, an aromatic aldehyde compound can be produced in high selectivity by a simple operation without using an expensive catalyst or transition metal.

  一种生产通式(3)代表的芳香醛化合物的工艺： (其中 R' 和 n 如下文所定义），该工艺包括使通式（1）所代表的苄基化合物发生反应： (其中 R 可代表氢原子，n 代表 1 至 6 的整数，R'可相同或不同，并代表氢原子或烷基高尔基、烷基或可带有取代基的苯基）与通式（2）所代表的溴的氧化合物反应： MBrOm (2) (其中 M 代表氢原子或金属原子，m 代表 1 至 3 的整数）在酸催化剂存在下进行反应。根据该方法，无需使用昂贵的催化剂或过渡金属，通过简单的操作即可生产出高选择性的芳香醛化合物。
• Process for producing aromatic nitrile compound
  申请人：Kawazoe Kentaro

  公开号：US20060069282A1

  公开（公告）日：2006-03-30

  A novel process for industrially producing an aromatic nitrile compound represented by the following general formula (3): characterized in that one of an aromatic hydroxymethyl compound, an aromatic alkoxymethyl compound and an aromatic aldehyde compound, all represented by the following general formula (1): or a mixture thereof is reacted with an oxidized bromine compound represented by the general formula (2) MBrO m (2) in the presence of an acid catalyst and either ammonia or an ammonium sat.

  一种工业化生产由以下通式（3）表示的芳香族腈化合物的新工艺： 或其混合物与通式（2）所代表的氧化溴化合物反应： 或其混合物与通式（2）代表的氧化溴化合物反应 MBrO m (2) 或其混合物在酸催化剂和氨或铵饱和物存在下与通式（2）MBrO m (2) 所表示的氧化溴化合物反应。
• PROCESS FOR PRODUCING AROMATIC NITRILE COMPOUND
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1555257B1

  公开（公告）日：2010-01-20
• FUNGICIDAL HETEROCYCLIC AROMATIC AMIDES AND THEIR COMPOSITIONS, METHODS OF USE AND PREPARATION
  申请人：Dow AgroSciences LLC

  公开号：EP1204643B1

  公开（公告）日：2008-06-04