Methyl 9-oxo-3-oxabicyclo[3.3.1]nonane-7-carboxylate | 851984-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: Methyl 9-oxo-3-oxabicyclo[3.3.1]nonane-7-carboxylate
• CAS: 851984-07-1
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.22
• InChiKey: DSUVBQLGYGGODF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP3135668A1

  公开（公告）日：2017-03-01

  This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein RA is, for example, a group of the following formula (A-1): wherein ring A1 is, for example, a cycloalkyl group which may be substituted, and RB is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新型二取代1,2,4-三嗪化合物或其药学上可接受的盐，该化合物具有醛固酮合成酶抑制活性，可用于预防和/或治疗与醛固酮相关的各种疾病或病症；本发明还提供了一种制备方法；本发明的用途；以及一种以本发明为活性成分的药物组合物。通式[I]的化合物： 其中RA例如为下式(A-1)的基团： 其中环 A1 例如是可被取代的环烷基、 RB例如为单环环烷基、 或其药学上可接受的盐。
• Disubstituted 1, 2, 4-triazine compound
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US10029993B2

  公开（公告）日：2018-07-24

  This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein RA is, for example, a group of the following formula (A-1): wherein ring A1 is, for example, a cycloalkyl group which may be substituted, and RB is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新型二取代1,2,4-三嗪化合物或其药学上可接受的盐，该化合物具有醛固酮合成酶抑制活性，可用于预防和/或治疗与醛固酮相关的各种疾病或病症；本发明还提供了一种制备方法；本发明的用途；以及一种以本发明为活性成分的药物组合物。通式[I]的化合物： 其中 RA 是例如下式（A-1）的基团： 其中，环 A1 例如是可被取代的环烷基，RB 例如是单环环烷基、 或其药学上可接受的盐。
• US7786305B2
  申请人：——

  公开号：US7786305B2

  公开（公告）日：2010-08-31