N-[2-[(2-pyridinyl)dithio]ethyl]-4-hydrazinobenzamide | 125428-62-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[(2-pyridinyl)dithio]ethyl]-4-hydrazinobenzamide
• 英文别名: 4-hydrazinyl-N-[2-(pyridin-2-yldisulfanyl)ethyl]benzamide
• CAS: 125428-62-8
• 化学式: C₁₄H₁₆N₄OS₂
• 分子量: 320.439
• InChiKey: IHHCILVYXOGFBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Water-based pesticidal composition
  申请人：Takemoto Yushi Kabushiki Kaisha

  公开号：EP0417896A1

  公开（公告）日：1991-03-20

  A water-based pesticidal composition contains 100 weight parts of substantially water-insoluble pesticide and 1.7-200 weight parts of a surface active agent. The surface-active agent contains Component A and Component B at weight ratio of A/B = 80/20 - 20/80. Component A is polyalkylene glycol ether derivative of polyethylene polyamine shown by the following general formula and having molecular weight of 20,000 - 100,000: where R¹, R², R³ and R⁴ are selected from the group consisting of hydrogen, alkyl group with 1-4 carbon atoms, alkanoyl group with 2-18 carbon atoms, alkenoyl group with 2-18 carbon atoms and polyoxyalkylene glycol group containing ethoxy(oxyethyne) unit and propoxy(oxypropylene) unit at weight ratio of (ethoxy unit/propoxy unit[oxyethyne unit/oxypropylene unit]=) 100/0 - 50/50, at least one of R¹, R², R³ and R4 being the polyoxyalkylene glycol group, and n is an integer 2 -250. Component B includes one or more selected from the group consisting of partial esters of polyhydric alcohol selected from sorbitol, sorbitan, glycerine and polyglycerine and unsaturated aliphatic acid with 16-22 carbon atoms and ethylene oxide adducts of such partial esters.

  一种水基杀虫剂组合物含有 100 重量份基本上不溶于水的杀虫剂和 1.7-200 重量份的表面 活性剂。 表面活性剂包含 A 组分和 B 组分，重量比为 A/B = 80/20 - 20/80。A 组分是聚乙烯多胺的聚亚烷基乙二醇醚衍生物，通式如下，分子量为 20,000 - 100,000： 其中 R¹、R²、R³ 和 R⁴ 选自氢、1-4 个碳原子的烷基、2-18 个碳原子的烷酰基组成的组、具有 2-18 个碳原子的烯酰基和含有乙氧基（氧乙炔）单元和丙氧基（氧丙 烯）单元的聚氧丙烯二醇基团，其重量比为（乙氧基单元/丙氧基单元[氧乙炔单 元/氧丙烯单元]=）100/0 - 50/50，R¹、R²、R³ 和 R4 中至少有一个是聚氧丙烯二醇基团，且 n 是 2 -250 的整数。B 组份包括选自山梨醇、山梨糖醇、甘油和聚甘油中的多元醇部分酯和具有 16-22 个碳原子的不饱和脂肪族酸以及此类部分酯的环氧乙烷加合物所组成的组中的一种或多种。
• Novel bifunctional linking compounds, conjugates and methods for their production
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0457250A2

  公开（公告）日：1991-11-21

  The present invention provides novel N-substituted hydrazine bifunctional compounds, novel N-substituted hydrazone derivatives of a cytotoxic reagent incorporating the bifunctional compounds, novel conjugates containing at least one cytotoxic reagent molecule reacted with the bifunctional compound and bound to a molecule reactive with a target cell population, methods for their production, and pharmaceutical compositions and methods for delivering cytotoxic reagents to a target population of cells. The hydrazone bonds of the conjugates of the invention permit the release of free cytotoxic reagent from the conjugates in the acidic external or internal environment of the target cells. The bifunctional compounds, derivatives, conjugates and methods of the invention are useful in antibody-or ligand-mediated drug delivery systems for the preferential killing of a target cell population to treat diseases such as cancers, infections and autoimmune disorders.

  本发明提供了新型 N-取代肼双官能团化合物、含有双官能团化合物的细胞毒性试剂的新型 N-取代腙衍生物、含有至少一个与双官能团化合物反应并与靶细胞群反应分子结合的细胞毒性试剂分子的新型共轭物、其生产方法以及向靶细胞群递送细胞毒性试剂的药物组合物和方法。本发明共轭物的腙键允许在靶细胞的酸性外部或内部环境中从共轭物中释放游离细胞毒性试剂。本发明的双功能化合物、衍生物、共轭物和方法可用于抗体或配体介导的给药系统，优先杀死靶细胞群，治疗癌症、感染和自身免疫性疾病等疾病。
• US5137877A
  申请人：——

  公开号：US5137877A

  公开（公告）日：1992-08-11
• US5349066A
  申请人：——

  公开号：US5349066A

  公开（公告）日：1994-09-20
• US5360783A
  申请人：——

  公开号：US5360783A

  公开（公告）日：1994-11-01