N-(2-(phenylsulfonyl)ethyl)hydroxylamine | 1126527-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-(phenylsulfonyl)ethyl)hydroxylamine
• 英文别名: N-[2-(benzenesulfonyl)ethyl]hydroxylamine
• CAS: 1126527-35-2
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.246
• InChiKey: XNESLFOAQJEJTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯乙基苯基砜 在 hydroxylamine hydrate 作用下， 以 甲醇 为溶剂， 100.0 ℃ 、2.41 MPa 条件下， 反应 0.17h， 以50%的产率得到N-(2-(phenylsulfonyl)ethyl)hydroxylamine
  参考文献：
  名称：

  连续流动中由氢氧化铵和羟胺化学选择性合成胺的方法

  摘要：

  连续流动实现烷基溴和氯化物与氨水和羟胺的化学选择性胺化，以高收率生产伯铵盐和羟胺。设计了在线后处理以分离相应的伯胺，该伯胺也可通过进一步反应进行缩合，例如酰化和Paal-Knorr吡咯合成。单取代的环氧化物也与反应条件相容。

  DOI：

  10.1021/acs.joc.8b02387

文献信息

• Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria
  申请人：Georgia State University Research Foundation, Inc.

  公开号：EP2529793A2

  公开（公告）日：2012-12-05

  The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.

  本公开包括可作为特异性 AI-2 拮抗剂用于控制细菌法定人数感应的化合物和组合物。尽管本公开的 AI-2 拮抗剂可能不具有杀菌作用，但其减弱毒性、耐药性和/或生物膜形成的能力具有治疗效果。此外，本公开的 AI-2 拮抗剂还可用作探究细菌 AI-2 功能的工具。本公开内容还包括抑制或减弱微生物毒力、生物膜形成和耐药性的方法。这些方法适用于防止细菌积累和形成广泛的生物膜，这些生物膜可能会危害健康或卫生，或造成物理问题，如堵塞水管或燃油管。
• COMPOSITIONS FOR REGULATING OR MODULATING QUORUM SENSING IN BACTERIA, METHODS OF USING THE COMPOUNDS, AND METHODS OF REGULATING OR MODULATING QUORUM SENSING IN BACTERIA
  申请人：Wang Binghe

  公开号：US20100137249A1

  公开（公告）日：2010-06-03

  The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
• US8653258B2
  申请人：——

  公开号：US8653258B2

  公开（公告）日：2014-02-18
• [EN] COMPOSITIONS FOR REGULATING OR MODULATING QUORUM SENSING IN BACTERIA, METHODS OF USING THE COMPOUNDS, AND METHODS OF REGULATING OR MODULATING QUORUM SENSING IN BACTERIA<br/>[FR] COMPOSITIONS PERMETTANT DE RÉGULER OU DE MODULER LA DÉTECTION DU QUORUM DANS UNE BACTÉRIE, PROCÉDÉS D'UTILISATION DE CES COMPOSÉS ET PROCÉDÉS DE RÉGULATION ET DE MODULATION DE LA DÉTECTION DU QUORUM DANS UNE BACTÉRIE
  申请人：UNIV GEORGIA STATE RES FOUND

  公开号：WO2009029317A2

  公开（公告）日：2009-03-05

  The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
• Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow
  作者：Clément Audubert、Alexanne Bouchard、Gary Mathieu、Hélène Lebel

  DOI：10.1021/acs.joc.8b02387

  日期：2018.11.16

  bromides and chlorides with aqueous ammonia and hydroxylamine was achieved in continuous flow to produce primary ammonium salts and hydroxylamines in high yields. An in-line workup was designed to isolate the corresponding primary amine, which was also telescoped in further reactions, such as acylation and Paal–Knorr pyrrole synthesis. Monosubstituted epoxides are also compatible with the reaction conditions

  连续流动实现烷基溴和氯化物与氨水和羟胺的化学选择性胺化，以高收率生产伯铵盐和羟胺。设计了在线后处理以分离相应的伯胺，该伯胺也可通过进一步反应进行缩合，例如酰化和Paal-Knorr吡咯合成。单取代的环氧化物也与反应条件相容。