3-((2,3,5,6-Tetrafluoro-3'-(trifluoromethoxy)biphenyl-4-yl)carbamoyl)thiophene-2-carboxylic acid | 717142-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((2,3,5,6-Tetrafluoro-3'-(trifluoromethoxy)biphenyl-4-yl)carbamoyl)thiophene-2-carboxylic acid
• 英文别名: 3-[[2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phenyl]phenyl]carbamoyl]thiophene-2-carboxylic acid
• CAS: 717142-73-9
• 化学式: C₁₉H₈F₇NO₄S
• 分子量: 479.3
• InChiKey: VNDUHYWEWRRBFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• [EN] AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS<br/>[FR] AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS
  申请人：4SC AG

  公开号：WO2004056797A1

  公开（公告）日：2004-07-08

  The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, for the use as a medicament.

  本发明涉及通式（II）化合物及其盐和生理功能衍生物，用于作为药物。
• Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
  申请人：4SC AG

  公开号：EP2283898A1

  公开（公告）日：2011-02-16

  The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, for the use as a medicament.

  本发明涉及通式（II）化合物及其盐类和生理功能衍生物，可用作药物。
• Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
  申请人：4SC AG

  公开号：US20040192758A1

  公开（公告）日：2004-09-30

  The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, 1 for the use as a medicament.

  本发明涉及通式（II）化合物及其盐类和生理功能衍生物、 1 用作药物。
• DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS
  申请人：Panoptes Pharma Ges.m.b.H.

  公开号：EP2427186B1

  公开（公告）日：2022-01-12
• AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS
  申请人：4SC AG

  公开号：EP1578741A1

  公开（公告）日：2005-09-28