1,4-Dimethoxy-2,5-bis[4-(trifluoromethyl)phenyl]benzene | 896732-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Dimethoxy-2,5-bis[4-(trifluoromethyl)phenyl]benzene
• CAS: 896732-25-5
• 化学式: C₂₂H₁₆F₆O₂
• 分子量: 426.358
• InChiKey: JJZJPVUSUAJXJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,4-Dimethoxy-2,5-bis[4-(trifluoromethyl)phenyl]benzene 在 ammonium cerium (IV) nitrate 作用下， 以 水 、 乙腈 为溶剂， 以65%的产率得到2,5-bis-(4-trifluoromethylphenyl)-1,4-benzoquinone
  参考文献：
  名称：

  Controlling Site Selectivity in Pd-Catalyzed Oxidative Cross-Coupling Reactions

  摘要：

  This paper presents a detailed investigation of the factors controlling site selectivity in the Pd-mediated oxidative coupling of 1,3-disubstituted and 1,2,3-trisubstituted arenes (aryl -H) with cyclometalating substrates (L similar to C-H). The influence of both the concentration and the steric/electronic properties of the quinone promoter are studied in detail. In addition, the effect of steric/electronic modulation of the carboxylate ligand is discussed. Finally, we demonstrate that substitution of the carboxylate for a carbonate X-type ligand leads to a complete reversal in site selectivity for many arene substrates. The origins of these trends in site selectivity are discussed in the context of the mechanism of Pd-catalyzed oxidative cross-coupling.

  DOI：

  10.1021/ja1097918

文献信息

• Terphenyl dihydroxy monomers containing fluorine and fluorinated poly(arylene ether sulfide)s
  申请人：Lee Jae-Suk

  公开号：US20060183878A1

  公开（公告）日：2006-08-17

  The present invention relates to terphenyl dihydroxy monomers containing fluorine and fluorinated poly(arylene ether sulfide)s prepared by using the monomers, more particularly, terphenyl dihydroxy monomers containing both two hydroxy functional groups and fluorine and fluorinated poly(arylene ether sulfide)s prepared by an aromatic nucleophilic substitution polymerization (S N Ar) using the monomers, which are thus useful as optical materials in the field of information telecommunications.
• TERPHENYL DIHYDROXY MONOMERS CONTAINING FLUORINE AND FLUORINATED POLY(ARYLENE ETHER SULFIDE)S
  申请人：LEE Jae-Suk

  公开号：US20090259017A1

  公开（公告）日：2009-10-15

  The present invention relates to terphenyl dihydroxy monomers containing fluorine and fluorinated poly(arylene ether sulfide)s prepared by using the monomers, more particularly, terphenyl dihydroxy monomers containing both two hydroxy functional groups and fluorine and fluorinated poly(arylene ether sulfide)s prepared by an aromatic nucleophilic substitution polymerization (S N Ar) using the monomers, which are thus useful as optical materials in the field of information telecommunications.
• US7732560B2
  申请人：——

  公开号：US7732560B2

  公开（公告）日：2010-06-08
• Controlling Site Selectivity in Pd-Catalyzed Oxidative Cross-Coupling Reactions
  作者：Thomas W. Lyons、Kami L. Hull、Melanie S. Sanford

  DOI：10.1021/ja1097918

  日期：2011.3.30

  This paper presents a detailed investigation of the factors controlling site selectivity in the Pd-mediated oxidative coupling of 1,3-disubstituted and 1,2,3-trisubstituted arenes (aryl -H) with cyclometalating substrates (L similar to C-H). The influence of both the concentration and the steric/electronic properties of the quinone promoter are studied in detail. In addition, the effect of steric/electronic modulation of the carboxylate ligand is discussed. Finally, we demonstrate that substitution of the carboxylate for a carbonate X-type ligand leads to a complete reversal in site selectivity for many arene substrates. The origins of these trends in site selectivity are discussed in the context of the mechanism of Pd-catalyzed oxidative cross-coupling.