tert-butyl 2-(3-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate | 1355016-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 2-(3-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate
• CAS: 1355016-65-7
• 化学式: C₂₈H₃₆ClN₅O₃
• 分子量: 526.079
• InChiKey: ZRTGKRBSBHNLGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.45
• 重原子数：
  37.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  79.7
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(3-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以44%的产率得到(4-(2-(3-(1H-benzo[d]imidazol-2-yl)propylamino)ethyl)piperazin-1-yl)(4-chlorophenyl)methanone
  参考文献：
  名称：

  4-Aminoethylpiperazinyl aryl ketones with 5-HT1A/5-HT7 selectivity

  摘要：

  The well-known 5-HT1A/5-HT7 selectivity issue was tackled by a new series of 4-aminoethylpiperazinyl aryl ketones (1a-1l) specifically designed to distinguish the two hydrophobic sites centered at the anchoring salt bridge. The 4-aminoethylpiperazinyl aryl ketones showed a wide spectrum of activity and selectivity for the 5-HT receptors depending on the type of the hydrophobic groups attached at the aryl piperazinyl ketone scaffold. Docking study of the most active compounds against 5-HT7R and 5-HT1AR revealed that both receptors have two hydrophobic pockets around the anchoring salt bridge. These two binding sites are perpendicular to each other in 5-HT7R but parallel in 5-HT1AR, and this observation is well matched with the previous report which claimed that 5-HT7R affinity arises from bent conformation of the bound ligand whereas an extended one is best suited for 5-HT1AR selectivity. Also, as these pockets have different size and shape, inhibitory activity as well as selectivity of the 4-aminoethylpiperazinyl aryl ketones against 5-HT7R and 5-HT1AR seemed to be determined by combination of two hydrophobic substituents attached at both ends of the title compounds. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.005
• 作为产物：
  描述：

  (4-(2-aminoethyl)piperazin-1-yl)(4-chlorophenyl)methanone 在 三乙酰氧基硼氢化钠 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 tert-butyl 2-(3-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)ethylamino)propyl)-1H-benzo[d]imidazole-1-carboxylate
  参考文献：
  名称：

  4-Aminoethylpiperazinyl aryl ketones with 5-HT1A/5-HT7 selectivity

  摘要：

  The well-known 5-HT1A/5-HT7 selectivity issue was tackled by a new series of 4-aminoethylpiperazinyl aryl ketones (1a-1l) specifically designed to distinguish the two hydrophobic sites centered at the anchoring salt bridge. The 4-aminoethylpiperazinyl aryl ketones showed a wide spectrum of activity and selectivity for the 5-HT receptors depending on the type of the hydrophobic groups attached at the aryl piperazinyl ketone scaffold. Docking study of the most active compounds against 5-HT7R and 5-HT1AR revealed that both receptors have two hydrophobic pockets around the anchoring salt bridge. These two binding sites are perpendicular to each other in 5-HT7R but parallel in 5-HT1AR, and this observation is well matched with the previous report which claimed that 5-HT7R affinity arises from bent conformation of the bound ligand whereas an extended one is best suited for 5-HT1AR selectivity. Also, as these pockets have different size and shape, inhibitory activity as well as selectivity of the 4-aminoethylpiperazinyl aryl ketones against 5-HT7R and 5-HT1AR seemed to be determined by combination of two hydrophobic substituents attached at both ends of the title compounds. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.005