Distereoface differentiating nucleophilic of thiophenol to olefins delivers a new concomitant asymmetric construction of two contiguous stereogenic centers and has been successfully applied to the asymmetric synthesis of (+)-diltiazem.
Distereoface区分
苯酚与
苯酚的亲核性,提供了一个新的伴随的两个不连续立体中心的不对称结构,并已成功地应用于(+)-地尔
硫m的不对称合成。