6-Chloro-5-methoxy-N-methyl-N-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)pyrimidin-4-amine | 1224097-07-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-Chloro-5-methoxy-N-methyl-N-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)pyrimidin-4-amine
• 英文别名: 6-chloro-5-methoxy-N-methyl-N-(2-methyl-6-methylsulfonylpyridin-3-yl)pyrimidin-4-amine
• CAS: 1224097-07-7
• 化学式: C₁₃H₁₅ClN₄O₃S
• 分子量: 342.806
• InChiKey: MKGXOEUMSGRWAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  93.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (6-chloro-5-methoxy-pyrimidin-4-yl)-(6-methanesulfonyl-2-methyl-pyridin-3-yl)-amine 、 碘甲烷 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 6-Chloro-5-methoxy-N-methyl-N-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)pyrimidin-4-amine
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS

  摘要：

  本发明涉及一种新型的三取代吡啶和三取代嘧啶衍生物的制备方法，其作为葡萄糖依赖性胰岛素受体激动剂，用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。

  公开号：

  US20100113480A1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PYRIDINE TRI-SUBSTITUÉE ET DE PYRIMIDINE TRI-SUBSTITUÉE UTILES COMME AGONISTES DU RÉCEPTEUR DU PEPTIDE INSULINOTROPE GLUCOSE-DÉPENDANT
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010059384A1

  公开（公告）日：2010-05-27

  The present invention is directed to novel processes for the preparation of th-substituted pyridine and tri-substituted pyrimidine derivatives, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.
• [EN] PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDNE DERIVATIVES USEFUL AS GDIR AGONISTS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PYRIDINE TRI-SUBSTITUÉE ET DE PYRIMIDINE TRI-SUBSTITUÉE UTILES COMME AGONISTES DU RÉCEPTEUR DU PEPTIDE INSULINOTROPE GLUCOSE-DÉPENDANT
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010059385A1

  公开（公告）日：2010-05-27

  The present invention is directed to novel processes for the preparation of th-substituted pyridine and tri-substituted pyrimidine derivatives, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.
• PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS
  申请人：Choudhury Anusuya

  公开号：US20100113479A1

  公开（公告）日：2010-05-06

  The present invention is directed to novel processes for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及一种制备三取代吡啶和三取代嘧啶衍生物的新型方法，其作为葡萄糖依赖性胰岛素促进受体激动剂，用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。