4-methoxy-N-(4-methoxyphenyl)-N-propan-2-ylaniline | 172782-54-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-methoxy-N-(4-methoxyphenyl)-N-propan-2-ylaniline
• CAS: 172782-54-6
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: FTNBSVGLSWDCBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxy-N-(4-methoxyphenyl)-N-propan-2-ylaniline 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 4,4'-(Isopropylazanediyl)diphenol
  参考文献：
  名称：

  Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton

  摘要：

  Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.004
• 作为产物：
  描述：

  4,4'-二甲氧基二苯胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-methoxy-N-(4-methoxyphenyl)-N-propan-2-ylaniline
  参考文献：
  名称：

  Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton

  摘要：

  Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.004

文献信息

• Novel organic electroluminescent compounds and organic electroluminescent device using the same
  申请人：Kim Young Gil

  公开号：US20100108997A1

  公开（公告）日：2010-05-06

  Provided are novel organic electroluminescent compounds, and organic electroluminescent devices comprising the same as electroluminescent material. Specifically, the organic electroluminescent compounds according to the present invention are represented by Chemical Formula (1): wherein, at least one substituent(s) among Ar 1 , Ar 2 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 and R 15 represent(s) The organic electroluminescent compounds according to the present invention exhibit high luminous efficiency and excellent life property of material, so that an OLED having very good operation life can be manufactured therefrom. Further, the organic electroluminescent compound according to the present invention, when it is contained in an electroluminescent layer or a hole transport layer, lowers the operation voltage to result in noticeable decrease in power consumption, with exhibiting at least comparable luminous efficiency as compared to conventional OLED's.
• Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton
  作者：Kiminori Ohta、Yuki Chiba、Takumi Ogawa、Yasuyuki Endo

  DOI：10.1016/j.bmcl.2008.08.004

  日期：2008.9

  Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. (C) 2008 Elsevier Ltd. All rights reserved.