N-(5-chloro-pyridin-2-yl)-N-piperidin-4-ylmethyl-propionamide trifluoroacetate | 1112990-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(5-chloro-pyridin-2-yl)-N-piperidin-4-ylmethyl-propionamide trifluoroacetate
• 英文别名: N-(5-chloropyridin-2-yl)-N-(piperidin-4-ylmethyl)propanamide;2,2,2-trifluoroacetic acid
• CAS: 1112990-92-7
• 化学式: C₂HF₃O₂*C₁₄H₂₀ClN₃O
• 分子量: 395.809
• InChiKey: CQATUTGLJCWPAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• N-PIPERIDIN-4-YLMETHYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  申请人：Peters Dan

  公开号：US20100204275A1

  公开（公告）日：2010-08-12

  This invention relates to novel N-piperidin-4-ylmethyl amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.

  这项发明涉及新颖的N-哌啶-4-基甲酰胺衍生物，可用作单胺神经递质再摄取抑制剂。在其他方面，该发明涉及将这些化合物用于治疗方法，以及包含该发明化合物的药物组合物。
• [EN] N-PIPERIDIN-4-YLMETHYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS<br/>[FR] DÉRIVÉS N-PIPÉRIDIN-4-YLMÉTHYL-AMIDE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RECAPTAGE DE NEUROTRANSMETTEURS MONOAMINES
  申请人：NEUROSEARCH AS

  公开号：WO2009016214A2

  公开（公告）日：2009-02-05

  This invention relates to novel N-piperidin-4-ylmethyl amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.