1-(3-Methylphenyl)piperidine-2,4-dione | 1518421-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(3-Methylphenyl)piperidine-2,4-dione
• CAS: 1518421-21-0
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.24
• InChiKey: GPBWVRVYIVBCSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
  申请人：Chen June

  公开号：US20070249596A1

  公开（公告）日：2007-10-25

  The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R 1 and R 2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound.

  本发明提供了一种治疗青光眼或眼压增高的方法，包括向需要治疗青光眼或眼压增高的人的眼睛中施加足够量的化合物I的方法，其中Y、Q、Z、R、R1和R2如规范中所定义。本发明还包括药物组合物，例如眼科组合物，包括所述化合物。
• Heterocyclic derivatives as abnormal cannabidiols agents for lowering intraocular pressure
  申请人：Allergan, Inc.

  公开号：EP2123264A1

  公开（公告）日：2009-11-25

  The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula (I), wherein Y, Q, Z, R, R1 and R2 are as defined in the specification. The present invention further comprises pharmaceutical composition, e.g. ophthalmic compositions, including said compound.

  本发明提供了一种治疗青光眼或眼压过高的方法，该方法包括向有需要的人的眼睛施用足以治疗青光眼或眼压过高的式(I)化合物，其中Y、Q、Z、R、R1和R2如说明书中所定义。本发明还包括药物组合物，如眼科组合物，包括所述化合物。
• US7968711B2
  申请人：——

  公开号：US7968711B2

  公开（公告）日：2011-06-28
• [EN] ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE<br/>[FR] CANNABIDIOLS ANORMAUX UTILES COMME AGENTS DESTINÉS À FAIRE BAISSER LA PRESSION INTRAOCULAIRE
  申请人：ALLERGAN INC

  公开号：WO2007127711A2

  公开（公告）日：2007-11-08

  [EN] The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula (I), wherein Y, Q, Z, R, R¹ and R² are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound.
  [FR] La présente invention concerne une méthode de traitement du glaucome ou de l'hypertension oculaire, cette méthode consistant à administrer dans l'oeil d'un patient une quantité suffisante, pour traiter le glaucome ou l'hypertension oculaire, d'un composé de formule (I) dans laquelle Y, Q, Z, R, R¹ et R² sont tels que définis dans le descriptif. La présente invention concerne également des compositions pharmaceutiques telles que des compositions ophtalmiques comprenant ce composé.