2-Cyclohex-2-enyl-4,6-dimethyl-phenol | 151474-63-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Cyclohex-2-enyl-4,6-dimethyl-phenol
• 英文别名: 2-Cyclohex-2-en-1-yl-4,6-dimethylphenol
• CAS: 151474-63-4
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: ISLXSSIYXSOREL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Cyclohex-2-enyl-4,6-dimethyl-phenol 在 碘 、 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 以78%的产率得到4-Iodo-6,8-dimethyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
  参考文献：
  名称：

  Stannic Chloride–Iodine: An Efficient Reagent for Regioselective Synthesis of Furan–Fused Heterocycles

  摘要：

  SnCl4-I-2-mediated cyclization of ortho-cyclohexenyl phenol and ortho-cyclohexenyl enol derivatives of coumarin, uracil, dimedone, and pyrone at room temperature for 1 h give the linear cyclized products in 78-90% yield, which, on treatment with 10% Pd-C at 250 degrees C for 1-2 h, afford corresponding aromatized products in 80-84% yield.

  DOI：

  10.1080/00397910701470982
• 作为产物：
  描述：

  1-Cyclohex-2-en-1-yloxy-2,4-dimethylbenzene 以 various solvent(s) 为溶剂， 反应 16.0h， 以75%的产率得到2-Cyclohex-2-enyl-4,6-dimethyl-phenol
  参考文献：
  名称：

  Majumdar, Krishna C.; Kundu, Anup K., Canadian Journal of Chemistry, 1995, vol. 73, # 10, p. 1727 - 1732

  摘要：

  DOI：

文献信息

• Cyclisation of<i>Ortho</i>-Cyclohexenyl Phenols<i>via</i>Epoxidation^#
  作者：K. C. Majumdar、P. Chatterjee、A. K. Kundu

  DOI：10.1080/00397919608004643

  日期：1996.9

  A number of ortho-cyclohexenyl phenols 2(a-i) have been cyclised by treatment with one equivalent of m-chloroperoxybenzoic acid in refluxing benzene for 4 h to furnish linearly fused 1-hydroxy-1,2,3,4,4a,9a-hexahydrodibenzofurans 3 (a-i) (70-80%) and bicyclic 3-hydroxy-1,3-ethanochromans 4(a-f) (10-20%). Products 3(a-i) were oxidised with 2,3-dichloro-5,6-dicyano-1 ,4-benzoquinone (excess) in refluxing dry xylene for 6 h to give 2,3-dihydrodibenzofuran-1 (2H)-ones 6(a-i) (85-95%).
• Hexamethylene Tetramine Hyorotribromide Mediated Regioselective Cyclisation of<i>Ortho</i>- Cyclohexenyl Phenols^#
  作者：K. C. Majumdar、A. K. Kundu、P. Chatterjee

  DOI：10.1080/00397919608003693

  日期：1996.3

  Hexamethylene tetramine hydrotribromide is found to be superior to pyridine hydrotribromide when compared with the rate of reaction and chemoselectivity for the regioselective cyclisation of a number of ortho-cyclohexenyl phenols 1(a-j) to 3-bromo-2,4-propano-chromans 2(a-j).
• Majumdar, K C; Kundu, A K, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 6, p. 605 - 606
  作者：Majumdar, K C、Kundu, A K

  DOI：——

  日期：——