6-(2,6-dichlorophenyl)-8-methoxy-2-(5-(2-pyrrolidinoethyl)aminocarbonyl-1-methylpyrrol-3-yl)aminopyrido[2,3-d]pyrimidin-7-one | 1021303-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2,6-dichlorophenyl)-8-methoxy-2-(5-(2-pyrrolidinoethyl)aminocarbonyl-1-methylpyrrol-3-yl)aminopyrido[2,3-d]pyrimidin-7-one
• 英文别名: 4-[[6-(2,6-dichlorophenyl)-8-methoxy-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-1-methyl-N-(2-pyrrolidin-1-ylethyl)pyrrole-2-carboxamide
• CAS: 1021303-64-9
• 化学式: C₂₆H₂₇Cl₂N₇O₃
• 分子量: 556.451
• InChiKey: JFOGVMSIWZJXFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27
• [EN] 8-OXY-2-AMINOPYRIDO (2, 3-D) PYRIMIDIN-7-ONE DERIVATIVES AS KINASE INHIBITORS AND ANTICANCER AGENTS<br/>[FR] INHIBITEURS DE KINASE
  申请人：GPC BIOTECH INC

  公开号：WO2008150260A1

  公开（公告）日：2008-12-11

  [EN] The present invention provides derivatives of pyrido [2, 3-d] pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
  [FR] La présente invention concerne des dérivés de pyrido[2,3-d]pyrimidin-7-one. Ces composés sont des inhibiteurs de kinase. Ils incluent des composés qui présentent une activité anti-proliférante, y compris contre les cellules tumorales, et se révèlent utiles dans le traitement de certaines maladies, du cancer entre autres.