(6R,9aS)-2-(3-chloro-4-fluorobenzyl)-6-(4-methoxy-2,3-dimethylphenyl)octahydropyrido[1,2-a]pyrazine | 869794-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (6R,9aS)-2-(3-chloro-4-fluorobenzyl)-6-(4-methoxy-2,3-dimethylphenyl)octahydropyrido[1,2-a]pyrazine
• 英文别名: (6R,9aS)-2-[(3-chloro-4-fluorophenyl)methyl]-6-(4-methoxy-2,3-dimethylphenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine
• CAS: 869794-09-2
• 化学式: C₂₄H₃₀ClFN₂O
• 分子量: 416.966
• InChiKey: XACSQXYOCJHHMD-WMZHIEFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Substituted 1-benzyl-4-substituted piperazine analogues
  申请人：Hutchison J. Alan

  公开号：US20060142301A1

  公开（公告）日：2006-06-29

  Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

  提供了式I的化合物，其中变量如此处所述：这些化合物可用于调节体内或体外MCH结合到MCH受体，并且在治疗人类、驯养宠物动物和家畜动物的各种代谢、进食和性功能失调方面特别有用。提供了用于治疗此类疾病的药物组合物和方法，以及用于检测MCH受体的配体的方法（例如，受体定位研究）。
• Substituted 1-Benzyl-4-Substituted Piperazine Analogues
  申请人：Hutchison J. Alan

  公开号：US20070249616A1

  公开（公告）日：2007-10-25

  Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

  提供了公式I的化合物，其中变量如此描述：这些化合物可以用于调节MCH与体内或体外的MCH受体结合，并且在治疗人类、家养伴侣动物和家畜动物的各种代谢、饮食和性功能障碍方面特别有用。提供了用于治疗这些疾病的制药组合物和方法，以及用于检测MCH受体（例如受体定位研究）的配体的方法。
• US7253168B2
  申请人：——

  公开号：US7253168B2

  公开（公告）日：2007-08-07