(4R)-4-methyl-3-propanoyl-1,3-oxazolidin-2-one | 1417575-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4R)-4-methyl-3-propanoyl-1,3-oxazolidin-2-one
• CAS: 1417575-41-7
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: LGEDTAWPPKYADR-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙酸酐 、 (R)-4-甲基-2-噁唑烷酮 在 (R)-HBTM 、 N,N-二异丙基乙胺 作用下， 以 氘代氯仿 为溶剂， 反应 3.0h， 生成 (4R)-4-methyl-3-propanoyl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Absolute Configuration of Lactams and Oxazolidinones Using Kinetic Resolution Catalysts

  摘要：

  A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.

  DOI：

  10.1021/ol303239t

文献信息

• Absolute Configuration of Lactams and Oxazolidinones Using Kinetic Resolution Catalysts
  作者：Matthew A. Perry、Jonathan V. Trinidad、Scott D. Rychnovsky

  DOI：10.1021/ol303239t

  日期：2013.2.1

  A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.