4-(5-hydroxypyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide | 1146543-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 4-(5-hydroxypyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide
• CAS: 1146543-69-2
• 化学式: C₁₀H₁₃N₅O₅S
• 分子量: 315.31
• InChiKey: ZRNZUUFSOIXQHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-(5-(benzyloxy)pyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide 在 palladium 10% on activated carbon 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以80%的产率得到4-(5-hydroxypyrimidin-2-yl)-N,N-dimethyl-3,5-dioxopiperazine-1-sulfonamide
  参考文献：
  名称：

  Multifunctional Compounds and Methods of Use Thereof

  摘要：

  提供了包含多功能剂的组合物和使用方法。

  公开号：

  US20090105269A1

文献信息

• Multifunctional Antioxidants for the Treatment of Age-Related Diseases
  作者：Hongxia Jin、James Randazzo、Peng Zhang、Peter F. Kador

  DOI：10.1021/jm901381j

  日期：2010.2.11

  Analogues of N,N-dimethyl-4-(pyrimidin-2-yl)piperazine-l-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS + CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select members of this series bind ions in the relative order of Cu1+ = Cu2+ >Fe2+ = Fe3+ > Zn2+ with no binding of Ca2+ or Mg2+ observed. In vitro evaluation of these compounds in human lens epithelial, human retinal pigmented epithelial, and human hippocampal astrocyte cell lines indicates that all analogues possessing the FRS group as well as the water-soluble vitamin E analogue 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid protect these cells against decreased cell viability and glutathione levels induced by hydrogen peroxide. In addition, those compounds possessing CHL groups also protected these cells against hydroxyl radicals generated by the Fenton reaction. These compounds are good candidates for the preventive treatment of cataract, age-related macular degeneration (AMD), and Alzheimer's dementia (AD).
• ANTIOXIDANT EYE DROPS
  申请人：Kador, Peter F.

  公开号：EP3203993A1

  公开（公告）日：2017-08-16
• US9173915B1
  申请人：——

  公开号：US9173915B1

  公开（公告）日：2015-11-03
• [EN] ANTIOXIDANT EYE DROPS<br/>[FR] COLLYRE ANTIOXYDANT
  申请人：KADOR PETER F

  公开号：WO2016057871A1

  公开（公告）日：2016-04-14

  The antioxidant eye drops is a topical ophthalmic formulation that contains four nutraceuticals (namely, astaxanthin, resveratrol, pyruvate and epigallocatechin gallate (EGCG)) having antioxidant, anti-inflammatory, and chelating activity in a carbomer gel carrier. The active ingredients can reduce oxidative stress through free radical scavenging and chelating activity. The carrier is composed of a solution of deionized water containing about 0.4% Carbopol 980 NF, 5.7% sorbitol. 0.01% cetrimide, 0.01% EDTA, and sodium chloride and sodium hydroxide in adequate amounts to adjust both the viscosity and the pH of the topical carrier to pH 7.0-7.4. Use of the formulation may delay the development of cataracts, reduce retinal degeneration, and maintain normal tear flow in dry eye due to the antioxidant, anti-inflammatory, and chelating activity of the active ingredients.