(3S,5S)-5-[(1S)-1-amino-2-(3,5-difluorophenyl)ethyl]-3-methyloxolan-2-one | 664372-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,5S)-5-[(1S)-1-amino-2-(3,5-difluorophenyl)ethyl]-3-methyloxolan-2-one
• CAS: 664372-79-6
• 化学式: C₁₃H₁₅F₂NO₂
• 分子量: 255.264
• InChiKey: SLDJFBRKZJOTMF-QILRFPOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl N-[(1S)-2-(3,5-difluorophenyl)-1-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]ethyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以100%的产率得到(3S,5S)-5-[(1S)-1-amino-2-(3,5-difluorophenyl)ethyl]-3-methyloxolan-2-one
  参考文献：
  名称：

  [EN] HYDROXYPROPYL AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  [FR] HYDROXYPROPYLAMIDES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER

  摘要：

  公开号：

  WO2005042472A3

文献信息

• Hydroxypropyl Amides for the Treatment of Alzheimer's Disease
  申请人：Tucker John

  公开号：US20070225374A1

  公开（公告）日：2007-09-27

  The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
• US7262208B2
  申请人：——

  公开号：US7262208B2

  公开（公告）日：2007-08-28
• [EN] HYDROXYPROPYL AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] AMIDES HYDROXYPROPYLE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ELAN PHARM INC

  公开号：WO2004058686A1

  公开（公告）日：2004-07-15

  The present invention relates to compounds of formula (I); useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta­secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
• [EN] HYDROXYPROPYL AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] HYDROXYPROPYLAMIDES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ELAN PHARM INC

  公开号：WO2005042472A3

  公开（公告）日：2006-07-20