2-chloro-N-[(S)-(3R,8aR)-(octahydroindolizin-3-yl)(thiophen-3-yl)methyl]-3-trifluoro-methylbenzamide hydrochloride | 1015468-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-[(S)-(3R,8aR)-(octahydroindolizin-3-yl)(thiophen-3-yl)methyl]-3-trifluoro-methylbenzamide hydrochloride
• 英文别名: N-[(S)-[(3R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizin-3-yl]-thiophen-3-ylmethyl]-2-chloro-3-(trifluoromethyl)benzamide;hydrochloride
• CAS: 1015468-01-5
• 化学式: C₂₁H₂₂ClF₃N₂OS*ClH
• 分子量: 479.394
• InChiKey: OLHOCWKNNWWZGC-NAKLVKNISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.33
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  60.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：Dargazanli Gihad

  公开号：US20100267766A1

  公开（公告）日：2010-10-21

  The disclosure relates to a compound of formula (I): wherein m, n, Ar, and R are as defined in the disclosure, to compositions containing them and to their therapeutic use. The disclosure also relates to processes for preparing these compounds and to certain intermediate compounds.