2-[3,5-dichloro-4-(2-chloro-6-fluoro-benzyloxy)-phenylcarbamoyl]-cyclopent-1-enecarboxylic acid | 1254036-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3,5-dichloro-4-(2-chloro-6-fluoro-benzyloxy)-phenylcarbamoyl]-cyclopent-1-enecarboxylic acid
• 英文别名: 2-[[3,5-Dichloro-4-[(2-chloro-6-fluoro-phenyl)methoxy]phenyl]carbamoyl]cyclopentene-1-carboxylic acid；2-[[3,5-dichloro-4-[(2-chloro-6-fluorophenyl)methoxy]phenyl]carbamoyl]cyclopentene-1-carboxylic acid
• CAS: 1254036-50-4
• 化学式: C₂₀H₁₅Cl₃FNO₄
• 分子量: 458.701
• InChiKey: QNIXUFHJBLJFFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS
  申请人：Panoptes Pharma Ges.m.b.H.

  公开号：EP2427186B1

  公开（公告）日：2022-01-12
• COMBINATIONAL THERAPY COMPRISING DHODH INHIBITOR AND METHOTREXATE FOR TREATING AUTOIMMUNE DISEASE
  申请人：4SC AG

  公开号：EP2362771A1

  公开（公告）日：2011-09-07
• MALEIMIDE-ALPHA-ALKYLSTYRENE-BASED TETRAPOLYMER WITH LOW MOLTEN VISCOSITY
  申请人：Korea Kumho Petrochemical Co., Ltd.

  公开号：EP2471821B1

  公开（公告）日：2017-02-01
• ANTI-INFLAMMATORY AGENTS AS VIROSTATIC COMPOUNDS
  申请人：VITT Daniel

  公开号：US20100280081A1

  公开（公告）日：2010-11-04

  The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, for the use as a medicament.
• COMBINATIONAL THERAPY FOR TREATING AUTOIMMUNE DISEASE
  申请人：Gröppel Manfred

  公开号：US20120028985A1

  公开（公告）日：2012-02-02

  The present invention relates to the treatment and prevention of immunological and inflammatory disorders with a compound of formula (I) in combination with methotrexate,