(1,3-benzodioxol-5-yl)-3-(6-chloro-5-phenyl-1H-indazol-3-yl)urea | 670749-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (1,3-benzodioxol-5-yl)-3-(6-chloro-5-phenyl-1H-indazol-3-yl)urea
• 英文别名: 1-(1,3-Benzodioxol-5-yl)-3-(6-chloro-5-phenyl-1H-indazol-3-yl)urea
• CAS: 670749-62-9
• 化学式: C₂₁H₁₅ClN₄O₃
• 分子量: 406.828
• InChiKey: HDMNKYUVOZUOEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  88.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Novel aminoindazole derivatives as medicaments and pharmaceutical compositions including them
  申请人：——

  公开号：US20040110956A1

  公开（公告）日：2004-06-10

  The present invention relates to novel derivatives of general formula (I) 1 in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C)cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO 2 R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO 2 , NH 2 , OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO 2 R8, NHSO 2 R8, SO 2 NR8R9, —O—SO 2 R8, —SO 2 —O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

  本发明涉及一般式(I)1的新衍生物，其中R3是(1-6C)烷基、芳基、芳基(1-6C)烷基、杂芳基、杂芳基(1-6C)烷基、芳基或杂芳基，与(1-10C)环烷基、杂环、杂环烷基、环烷基、脱氢环戊基、多环烷基、烯基、炔基、CONR1R2、COOR1、SO2R1、C(═NH)R1或C(═NH)NR1基团融合；R5和R6分别选择自以下基团：卤素、CN、NO2、NH2、OH、COOH、C(O)OR8、—O—C(O)R8、NR8R9、NHC(O)R8、C(O)NR8R9、NHC(S)R8、C(S)NR8R9、SR8、S(O)R8、SO2R8、NHSO2R8、SO2NR8R9、—O—SO2R8、—SO2—O—R8、三氟甲基、三氟甲氧基、(1-6C)烷基、(1-6C)烷氧基、芳基、芳基(1-6C)烷基、杂芳基、杂芳基(1-6C)烷基、杂环、环烷基、烯基、炔基、脱氢环戊基或多环烷基。
• NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
  申请人：Lesuisse Dominique

  公开号：US20070093479A1

  公开（公告）日：2007-04-26

  The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO 2 R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO 2 , NH 2 , OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO 2 R8, NHSO 2 R8, SO 2 NR8R9, —O—SO 2 R8, —SO 2 —O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

  本发明涉及一般式（I）的新衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（═NH）R1或C（═NH）NR1基团融合；R5和R6独立地选择以下基团：卤素，CN，NO2，NH2，OH，COOH，C（O）OR8，—O—C（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，—O—SO2R8，—SO2—O—R8，三氟甲基，三氟甲氧基，（1-6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环环烷基。
• DERIVES DE 3-AMINOINDAZOLE COMME INHIBITEURS DE KINASE ET COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
  申请人：Aventis Pharma S.A.

  公开号：EP1537087B1

  公开（公告）日：2012-11-28
• US7166629B2
  申请人：——

  公开号：US7166629B2

  公开（公告）日：2007-01-23
• US7582669B2
  申请人：——

  公开号：US7582669B2

  公开（公告）日：2009-09-01