1-(3-{2-[3-(4-methoxypyrimidin-2-yl)pyrrolidin-1-yl]ethyl}pyridin-2-yl)piperidin-2-one | 1430091-43-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3-{2-[3-(4-methoxypyrimidin-2-yl)pyrrolidin-1-yl]ethyl}pyridin-2-yl)piperidin-2-one
• 英文别名: 1-[3-[2-[3-(4-Methoxypyrimidin-2-yl)pyrrolidin-1-yl]ethyl]pyridin-2-yl]piperidin-2-one
• CAS: 1430091-43-2
• 化学式: C₂₁H₂₇N₅O₂
• 分子量: 381.478
• InChiKey: CDZWKLMNHLGKSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  71.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] 2-OXO-PIPERIDINYL DERIVATIVES<br/>[FR] DERIVES DE 2-OXO-PIPÉRIDINYLE
  申请人：UCB PHARMA SA

  公开号：WO2013053725A1

  公开（公告）日：2013-04-18

  The present invention relates to 2-oxo-piperidinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及2-氧代哌啶基衍生物，其制备方法，含有它们的药物组合物以及它们作为药物的用途。
• 2-Oxo-Piperidinyl Derivatives
  申请人：UCB Pharma, S.A.

  公开号：US20150011526A1

  公开（公告）日：2015-01-08

  The present invention relates to 2-oxo-piperidinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

  本发明涉及2-氧代哌啶基衍生物、其制备过程、含有它们的制药组合物以及它们作为药物的用途。
• PROCESS FOR THE CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS, NOVEL CARBONYLATION LIGANDS AND CATALYST SYSTEMS INCORPORATING SUCH LIGANDS
  申请人：Lucite International UK Limited

  公开号：US20150011758A1

  公开（公告）日：2015-01-08

  A novel bidentate ligand of general formula (I) is described together with a process for the carbonylation of ethylenically unsaturated compounds. The group X 1 may be defined as a univalent hydrocarbyl radical of up to 30 atoms containing at least one nitrogen atom having a pKb in dilute aqueous solution at 18° C. of between 4 and 14 wherein the said at least one nitrogen atom is separated from the Q 2 atom by between 1 and 3 carbon atoms. The group X 2 is defined as X 1 , X 3 or X 4 or represents a univalent radical of up to 30 atoms having at least one primary, secondary or aromatic ring carbon atom wherein each said univalent radical is joined via said at least one primary, secondary or aromatic ring carbon atom(s) respectively to the respective atom Q 2 . Q 1 and Q 2 each independently represent phosphorus, arsenic or antimony.

  本发明涉及一种一般式(I)的新型双齿配体，以及一种用于羰基化乙烯基不饱和化合物的方法。其中，基团X1可以定义为具有最多30个原子的一价烃基基团，其中至少含有一个氮原子，在18℃下的稀溶液中pKb值在4到14之间，且所述至少一个氮原子与Q2原子之间相隔1到3个碳原子。基团X2被定义为X1、X3或X4，或表示具有至少一个一级、二级或芳香环碳原子的最多30个原子的一价基团，其中每个所述一价基团分别通过所述至少一个一级、二级或芳香环碳原子与相应的Q2原子连接。Q1和Q2各自独立地表示磷、砷或锑。
• 2-OXO-PIPERIDINYL DERIVATIVES
  申请人：UCB Pharma, S.A.

  公开号：EP2766353A1

  公开（公告）日：2014-08-20
• US9067930B2
  申请人：——

  公开号：US9067930B2

  公开（公告）日：2015-06-30