(R,R)-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine | 638261-01-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (R,R)-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine
• 英文别名: (1R,2R)-1,2-Bis[3-(benzyloxy)phenyl]ethane-1,2-diamine；(1R,2R)-1,2-bis(3-phenylmethoxyphenyl)ethane-1,2-diamine
• CAS: 638261-01-5
• 化学式: C₂₈H₂₈N₂O₂
• 分子量: 424.543
• InChiKey: ULNILMBTNHAFIN-VSGBNLITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R,R)-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、1000.0 kPa 条件下， 反应 2.0h， 生成 (R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-hydroxyphenyl)ethane-1,2-diamine
  参考文献：
  名称：

  Asymmetric Hydrogenation of Ketones with Polymer-Supported Chiral 1,2-Diphenylethylenediamine

  摘要：

  A poly(ethylene glycol)-supported chiral diamine (PEG-2), in which the polymer is attached to the phenyl rings, has been synthesized and shown to be highly effective in asymmetric hydrogenation of unfunctionalized aromatic ketones with the possibility of reuse. PEG-2 can also serve as a chiral scaffold on which various immobilized chiral catalysts could be easily built.

  DOI：

  10.1021/ol0355837

文献信息

• Nitrogen-containing ligands
  申请人：Hems Patrick William

  公开号：US20060135355A1

  公开（公告）日：2006-06-22

  An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R 5 , R 6 , R 7 and R 8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R 1 , R 2 , R 3 , and R 4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R 1 , R 2 , R 3 and R 4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.

  描述了一种固定化含氮配体，其包括式(I)的化合物的反应产物，其中R5、R6、R7和R8独立地为氢、饱和或不饱和的C1-C10烷基、芳基、脲基、磺酰基或形成亚胺基，R1、R2、R3和R4独立地为氢、饱和或不饱和的C1-C10烷基或芳基，且其中至少一个R1、R2、R3和R4被官能团官能化，以及具有能与所述官能团反应的位点的固体支持。该含氮配体可用于制备固定化催化剂，用于进行不对称催化等反应。
• Immobilisable ligands derived from ethylenediamine
  申请人：Johnson Matthey PLC

  公开号：EP1676635A2

  公开（公告）日：2006-07-05

  A ligand of formula (I) is described wherein R1, R3, R5, R6, R7 and R8 are hydrogen, characterized in that R2 and R4 are functional group-containing aryl groups in which the functional groups are selected from the group consisting of halogen (Cl, Br, F or I), hydroxyl, alkoxy, carbonyl, carboxyl, anhydride, carbene, methacryl, epoxide, vinyl, nitrile, mercapto, amine, imine, amide and imide. The ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.

  描述了一种式 (I) 配体 其中 R1、R3、R5、R6、R7 和 R8 为氢，其特征在于 R2 和 R4 为含官能团的芳基，其中官能团选自由卤素（Cl、Br、F 或 I）、羟基、烷氧基、羰基、羧基、酸酐、碳烯基、甲基丙烯酸酯、环氧化物、乙烯基、腈、巯基、胺、亚胺、酰胺和亚胺组成的组。配体可用于制备进行不对称催化等的固定化催化剂。
• Asymmetric transfer hydrogenation of ketones with a polymer-supported chiral diamine
  作者：Xiaoguang Li、Weiping Chen、William Hems、Frank King、Jianliang Xiao

  DOI：10.1016/j.tetlet.2003.11.104

  日期：2004.1

  A new supported chiral diamine has been developed and shown to be highly effective in ruthenium-catalysed asymmetric transfer hydrogenation of simple aromatic ketones. (C) 2003 Elsevier Ltd. All rights reserved.
• NITROGEN-CONTAINING LIGANDS
  申请人：Johnson Matthey PLC

  公开号：EP1545772A2

  公开（公告）日：2005-06-29
• [EN] NITROGEN-CONTAINING LIGANDS<br/>[FR] LIGANDS CONTENANT DE L'AZOTE
  申请人：JOHNSON MATTHEY PLC

  公开号：WO2004014551A2

  公开（公告）日：2004-02-19

  An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R1, R2, R3 , and R4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R1, R2, R3 and R4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.