(R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine
• 英文别名: tert-butyl N-[(1R,2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,2-bis(3-phenylmethoxyphenyl)ethyl]carbamate
• 化学式: C₃₈H₄₄N₂O₆
• 分子量: 624.777
• InChiKey: AYCWHBJTYBTUHT-KKLWWLSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  46
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、999.99 kPa 条件下， 反应 2.0h， 以94%的产率得到(R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-hydroxyphenyl)ethane-1,2-diamine
  参考文献：
  名称：

  Asymmetric Hydrogenation of Ketones with Polymer-Supported Chiral 1,2-Diphenylethylenediamine

  摘要：

  A poly(ethylene glycol)-supported chiral diamine (PEG-2), in which the polymer is attached to the phenyl rings, has been synthesized and shown to be highly effective in asymmetric hydrogenation of unfunctionalized aromatic ketones with the possibility of reuse. PEG-2 can also serve as a chiral scaffold on which various immobilized chiral catalysts could be easily built.

  DOI：

  10.1021/ol0355837
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 (R,R)-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到(R,R)-N,N-bis-tert-butyloxycarbonyl-1,2-di(3-benzyloxyphenyl)ethane-1,2-diamine
  参考文献：
  名称：

  Asymmetric Hydrogenation of Ketones with Polymer-Supported Chiral 1,2-Diphenylethylenediamine

  摘要：

  A poly(ethylene glycol)-supported chiral diamine (PEG-2), in which the polymer is attached to the phenyl rings, has been synthesized and shown to be highly effective in asymmetric hydrogenation of unfunctionalized aromatic ketones with the possibility of reuse. PEG-2 can also serve as a chiral scaffold on which various immobilized chiral catalysts could be easily built.

  DOI：

  10.1021/ol0355837