| 352309-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 352309-37-6
• 化学式: C₁₇H₂₅N₄O₄*I
• 分子量: 476.314
• InChiKey: UWGGXQDYJHIUIX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-Nitrobenzyl (1S,5R,6S)-2-[6-(3-bromomethyl-benzyl)-7-methylthioimidazo[5,1-b]thiazolium-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate bromide 、 以 氯仿 、 乙腈 为溶剂， 生成 4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxy-ethyl)-1-methyl-2-[6-[3-[4-[3-(4-nitrobenzyloxycarbonyl-amino)propyl]-1,4-diazoniabicyclo[2,2,2]oct-1-yl]methyl-benzyl]-7-methylthioimidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate iodide dibromide
  参考文献：
  名称：

  Synthesis of novel di- and tricationic carbapenems with potent anti-MRSA activity

  摘要：

  A new series of 1 beta-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus was prepared, and their activities against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. First, a benzyl moiety was introduced at the C-6 position of imidazo[5,1-b]thiazole attached to the carbapenem. These benzylated molecules showed potent anti-MRSA activity, but poor water solubility. In order to overcome this drawback, we designed and synthesized di- and tricationic carbapenems and finally discovered a novel carbapenem (15i), which exhibited excellent anti-MRSA activity and good water solubility. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.039