3-Amino-6-(5-methoxycarbonyl-isoxazol-3-yl)-4-oxy-pyrazine-2-carboxylic acid ethyl ester | 131684-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Amino-6-(5-methoxycarbonyl-isoxazol-3-yl)-4-oxy-pyrazine-2-carboxylic acid ethyl ester
• CAS: 131684-26-9
• 化学式: C₁₂H₁₂N₄O₆
• 分子量: 308.25
• InChiKey: QPFVDWILHKJVJP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-amino-3-carbethoxy-5-<(hydroxyimino)methyl>pyrazine-1-oxide 、 丙炔酸甲酯 在 N-氯代丁二酰亚胺 、 三乙胺 作用下， 生成 3-Amino-6-(5-methoxycarbonyl-isoxazol-3-yl)-4-oxy-pyrazine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Pteridines. 54. A novel synthetic approach to C-6 carbon substituted pterins via intermolecular 1,3-dipolar cycloaddition reactions

  摘要：

  A number of 5-[(hydroxyimino)methyl]pyrazines and 6-[(hydroxyimino)methyl]pterins were converted to their respective nitrile oxides in the presence of dipolarophiles to give side-chain isoxazoles and isoxazolines as potential intermediates for the construction of multifunctional C-6 pterin substituents.

  DOI：

  10.1021/jo00005a028