Perfluoro-2-methylheptane | 153273-32-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: Perfluoro-2-methylheptane
• 英文别名: 1,1,1,2,2,3,3,4,4,5,5,6,7,7,7-pentadecafluoro-6-(trifluoromethyl)heptane
• CAS: 153273-32-6
• 化学式: C₈F₁₈
• 分子量: 438.06
• InChiKey: CTUHKFIIVLKIOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  18

文献信息

• Process for chlorination and chlorosulfonation of olefin polymers in suspensions of perfluorinated liquids
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0608802A2

  公开（公告）日：1994-08-03

  Olefin polymers of melt index 1-500g/10 minutes are chlorinated or chlorosulfonated in perfluorinated alkane, perfluorinated ether, or perfluorinated tertiary amine suspension.

  熔融指数为 1-500g/10 分钟的烯烃聚合物在全氟烷烃、全氟醚或全氟叔胺悬浮液中进行氯化或氯磺化。
• Process for preparing fluorochemicals
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0643155A2

  公开（公告）日：1995-03-15

  A process for preparing fluorochemical compounds, e.g., perfluoroalkanes, perfluoroethers, and perfluoroalkyl tertiary amines, comprises (a) forming a mixture comprising at least one fluorinatable, non-functional organic starting compound, e.g., propane, and at least one other compound which is present in an amount sufficient to enable the formation of a fluorochemical phase and which is selected from the group consisting of (i) perfluorochemical compounds, e.g., perfluorohexane, which boil at a higher temperature than either the fluorinatable, non-functional organic starting compound or the fluorochemical compound resulting from the subsequent fluorination of the fluorinatable, non-functional organic starting compound; and (ii) precursor compounds, e.g., hexane, which can be fluorinated in situ to produce such perfluorochemical compounds; and (b) subjecting the mixture to electrochemical fluorination in the presence of anhydrous hydrogen fluoride.

  一种制备氟化合物（如全氟烷烃、全氟醚和全氟烷基叔胺）的工艺包括 (a) 形成一种混合物，该混合物包括至少一种可氟化的非官能有机起始化合物（如丙 烷）和至少一种其它化合物，其含量足以形成氟化学相，该化合物选自以下组别： (b) 将至少一种可氟化的非官能有机起始化合物（如丙烷）和至少一种其它化合物（其 含量足以形成氟化学相，该化合物选自以下组别 (i) 全氟化合物，如全氟己烷，其沸腾温度高于可氟化的非功能性有机起始化合物或可氟化的非功能性有机起始化合物随后氟化产生的氟化合物；以及 (ii) 可就地氟化以生产此类全氟化合物的前体化合物，如正己烷；以及 (b) 在无水氟化氢存在下，对混合物进行电化学氟化。
• ULTRASONIC DRUG DELIVERY SYSTEM FOR DENTAL USE AND ULTRASONIC DRUG DELIVERY METHOD FOR DENTAL USE
  申请人：Japan Health Sciences Foundation

  公开号：EP2514387A1

  公开（公告）日：2012-10-24

  A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800. The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800. The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.

  本发明提供了一种牙科超声波给药系统，能够准确清洁根管内部并杀死牙本质小管中的细菌。牙科超声波给药系统使用超声波给药装置 800 将药物输送到目标物。药物以与纳米气泡混合的状态输送。用于应用超声波的牙科治疗探针连接到超声波给药装置 800 上。牙科治疗探针选自：(1) 根管插入探针 100，其配置为插入根管并使超声波在根管中传播；(2) 龋齿治疗探针，其使超声波在龋齿部分传播；(3) 牙周疾病治疗探针，其对牙周疾病部分施加超声波；以及 (4) 过度兴奋治疗探针，其对过度兴奋部分施加超声波。
• THERANOSTIC BUBBLE PREPARATION (TB), AND METHOD FOR USING SAME
  申请人：Teikyo University

  公开号：EP3308779A1

  公开（公告）日：2018-04-18

  Provided is a theranostic bubble preparation which makes it possible diagnose and treat a tissue of interest through irradiation with diagnostic ultrasound and irradiation with low intensity therapeutic ultrasound. The theranostic bubble preparation contains bubbles each including a coating of lipid and a gas encapsulated in an inner cavity defined by the coating. The lipid forming the coating is an anionic lipid including distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and mixed gas include perfluoropropane or perfluorobutane.

  本发明提供了一种治疗性气泡制剂，它可以通过诊断性超声波照射和低强度治疗性超声波照射对相关组织进行诊断和治疗。这种治疗性气泡制剂含有气泡，每个气泡包括一层脂质涂层和封装在由涂层限定的内腔中的气体。形成涂层的脂质是一种阴离子脂质，包括二硬脂酰磷脂酰胆碱（DSPC）、二硬脂酰磷脂酰甘油（DSPG）和 1,2-二硬脂酰-sn-甘油-3-磷脂酰乙醇胺-N-[甲氧基（聚乙二醇）-2000]（DSPE-PEG2000）。气体和混合气体包括全氟丙烷或全氟丁烷。
• Theranostic bubble preparation (TB), and method for using same
  申请人：TEIKYO UNIVERSITY

  公开号：US10688199B2

  公开（公告）日：2020-06-23

  Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.

  本发明提供了一种治疗气泡制剂，通过超声波（如诊断性超声波和低强度治疗性超声波）的照射，可对相关组织进行诊断和治疗。这种治疗气泡制剂包括：由脂质组成的涂膜；以及封闭在涂膜形成的内腔中的气体。涂膜包括由二硬脂酰磷脂酰胆碱（DSPC）、二硬脂酰磷脂酰甘油（DSPG）和 1,2-二硬脂酰-sn-甘油-3-磷乙醇胺-N-[甲氧基（聚乙二醇）-2000]（DSPE-PEG2000）制成的阴离子脂质。气体和混合气体包括全氟丙烷或全氟丁烷。