2-(4-Phenylbutoxy)oxane | 333742-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-(4-Phenylbutoxy)oxane
• CAS: 333742-34-0
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: ZJFHEDOZPSVXCD-UHFFFAOYSA-N

物化性质

• 沸点：
  354.7±42.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Phenylbutoxy)oxane 在 indium(III) triflate 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以92%的产率得到4-苯基丁醇
  参考文献：
  名称：

  A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

  摘要：

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01864-6
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 4-苯基丁醇 在 吡啶盐酸盐 作用下， 反应 0.08h， 以90%的产率得到2-(4-Phenylbutoxy)oxane
  参考文献：
  名称：

  Tetrahydropyranylation of Alcohols Under Solvent-Free Conditions

  摘要：

  A green, efficient, and large-scale method for tetrahydropyranylation of alcohols in the presence of a catalytic amount of pyridinium chloride at room temperature under solvent-free conditions is reported.

  DOI：

  10.1080/00397910802499518

文献信息

• Yb(OTf)3/FeCl3 mediated facile conversion of alcohols, ketals and acid sensitive ethers into diphenylmethyl (DPM) ethers
  作者：G.V.M. Sharma、T. Rajendra Prasad、A.K. Mahalingam

  DOI：10.1016/s0040-4039(00)02108-0

  日期：2001.1

  10 mol% Yb(OTf)3 or FeCl3 have been developed as efficient reagents for the conversion of alcohols into diphenylmethyl (DPM) ethers. Similarly, FeCl3 has also been advantageously utilised to successfully convert ketals and acid sensitive ethers into DPM ethers.

  已开发出10 mol％的Yb（OTf）3或FeCl 3作为将醇转化为二苯甲基（DPM）醚的有效试剂。类似地，FeCl 3也已被有利地用于成功地将缩酮和对酸敏感的醚转化为DPM醚。
• ZrCl4 as a mild and efficient catalyst for the one-pot conversion of TBS and THP ethers to acetates
  作者：Ch.Sanjeeva Reddy、G Smitha、S Chandrasekhar

  DOI：10.1016/s0040-4039(03)01078-5

  日期：2003.6

  A mild, efficient and chemoselective method has been developed for the direct transformation of tert-butyldimethylsilyl and tetrahydropyranyl protected alcohols into the corresponding acetates with acetic anhydride and zirconium(IV) chloride as the catalyst in acetonitrile, in a one-pot reaction with high yields and short reaction times. This method has been applied to a variety of substrates. (C) 2003 Elsevier Science Ltd. All rights reserved.