N-(2-aminoethyl)-N-propyl-1,2-ethanediamine | 30935-66-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-aminoethyl)-N-propyl-1,2-ethanediamine
• 英文别名: N'-(2-aminoethyl)-N'-propylethane-1,2-diamine
• CAS: 30935-66-1
• 化学式: C₇H₁₉N₃
• 分子量: 145.248
• InChiKey: UDNAQNGAEGGPGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,5-diamino-6-chloropyrazin-2-yl)(1H-imidazol-1-yl)methanone 、 N-(2-aminoethyl)-N-propyl-1,2-ethanediamine 在 triamine 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以There was obtained 24.64 g (78.0 mmol, 78%) of 3,5-diamino-N-[2-[(2-aminoethyl)propylamino]ethyl]-6-chloropyrazinecarboxamide as a yellow solid的产率得到3,5-diamino-N-[2-[(2-aminoethyl)propylamino]ethyl]-6-chloropyrazinecarboxamide
  参考文献：
  名称：

  Aminophenol derivatives

  摘要：

  某些含有胺基酚基吡嗪的化合物III具有平衡钾利尿作用，并且在治疗需要平衡钾利尿作用的疾病和病况中具有价值，例如在治疗水肿、高血压和/或相关疾病中。

  公开号：

  US04952583A1

文献信息

• Compounds that are Analogs of Squalamine, Used as Antibacterial Agents
  申请人：VIRBAC

  公开号：US20180042942A1

  公开（公告）日：2018-02-15

  The invention relates to compounds of formula (I), to the pharmaceutical compositions comprising same, and to the use thereof in the treatment of bacterial, fungal, viral and parasitic infections or in the treatment of cancer in humans or animals. In formula (I), R1 and R2 are as defined in claim 1.

  这项发明涉及公式（I）的化合物，包括相同的药物组成，以及在人类或动物中用于治疗细菌、真菌、病毒和寄生虫感染或治疗癌症的用途。在公式（I）中，R1和R2如权利要求1中定义的那样。
• DIVERGENT SYNTHESIS OF LOOPED POLY(ESTER)-AND POLY(ETHER)-SUBSTITUTED DENDRONS AND DENDRIMERS
  申请人：Tomalia Donald A.

  公开号：US20100086482A1

  公开（公告）日：2010-04-08

  The present invention describes a process for preparing new looped dendrimer and dendron compounds by controlling the molar amount of branch cell reagent monomer that is combined with various cores bearing core-XR functionalities (e.g., primary, or secondary amines, thiol, or epoxy functionalities). These looped, macrocyclic structures are more robust to various conditions, with greater resistance to acid/base hydrolysis. Alternatively, the looped, macrocyclic structure may offer new orientations that would qualify it as a better chelation ligand for metals, and other similar uses.

  本发明描述了一种通过控制与带有核心-XR功能基团（例如，主要或次要胺基，硫醇或环氧基团）的各种核心结构相结合的支链细胞试剂单体的摩尔量来制备新的环形树状分子和树状化合物的过程。这些环形的大环结构在各种条件下更加稳健，对酸碱水解有更强的抵抗力。另外，这种环形的大环结构可能提供新的取向，使其成为更好的金属螯合配体以及其他类似用途的合适选择。
• Aminomethylphenolic pyrazines
  申请人：ICI Americas Inc.

  公开号：US04910202A1

  公开（公告）日：1990-03-20

  This invention comprises novel pyrazine amides which are useful as eukalemic diuretics.

  这项发明涵盖了一种新型的吡嗪酰胺，其可用作平衡钾的利尿剂。
• Amine-Containing Transfection Reagents and methods for making and using same
  申请人：Yang Zhiwei

  公开号：US20120136073A1

  公开（公告）日：2012-05-31

  There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

  本文提供了一种新型含胺转染化合物及其制备和使用方法。这些化合物通常是通过将一种一级胺与一种不饱和化合物反应而得到的。本文还提供了使用含胺转染化合物与其他化合物结合以封装生物活性物质（如核酸）的转染复合物。还描述了使用该转染复合物进行体内或体外生物活性物质递送的方法。本发明的转染复合物非常有效，因此相对于已知的类似转染化合物，可以在相对较低的剂量下有效调节生物活性。
• BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20150267196A1

  公开（公告）日：2015-09-24

  A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition.

  一种组合物包括可生物降解的水凝胶，该水凝胶包括水凝胶形成基础聚合物和多种生理降解的酯键、酰胺键、偶氮-炔环加成键、丙烯酸基-硫醇键、脲键和/或甲基丙烯酸基-硫醇键，以及与多核苷酸耦合的聚合分子；和多核苷酸。在生理条件下，该多核苷酸以空间和/或时间受控或预定的方式从该组合物中释放出来。