(1S,2S)-2-{[(6-methyl-2-pyridyl)methyl]amino}-1-phenyl-1-propanol | 1200378-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1S,2S)-2-{[(6-methyl-2-pyridyl)methyl]amino}-1-phenyl-1-propanol
• CAS: 1200378-61-5
• 化学式: C₁₆H₂₀N₂O
• 分子量: 256.348
• InChiKey: DIQPGPVWZGJEIS-BBRMVZONSA-N

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 (1S,2S)-2-{[(6-methyl-2-pyridyl)methyl]amino}-1-phenyl-1-propanol
  参考文献：
  名称：

  N-Pyridylmethylephedrine derivatives in the catalytic asymmetric addition of diethylzinc to aldehydes and diphenylphosphinoylimines

  摘要：

  N-Pyridylmethyl-substituted Ephedra derivatives were synthesized by either direct alkylation or reductive alkylation of (1R,2S)-norephedrine, (1S,2S)-pseudo norephedrine, and (1R,2S)-ephedrine. These derivatives were then employed in asymmetric addition reactions with diethylzinc and aldehydes and diphenylphosphinoylimines. The use of the diastereomers from the Ephedra family allowed for a systematic evaluation of the contribution of the N-pyridylmethyl. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.08.014