5-(Hydroxymethyl)-1-(4-methoxyphenyl)-2(1H)-pyridinone | 1221423-74-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(Hydroxymethyl)-1-(4-methoxyphenyl)-2(1H)-pyridinone
• 英文别名: 5-(hydroxymethyl)-1-(4-methoxyphenyl)pyridin-2-one
• CAS: 1221423-74-0
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.25
• InChiKey: WIEIVHBRACVLNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CALCIUM RECEPTOR MODULATING AGENTS
  申请人：Fotsch Christopher

  公开号：US20110230517A1

  公开（公告）日：2011-09-22

  The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy 1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy 2 is phenyl naphthyl.

  本发明涉及新型钙敏感剂化合物及包含它们的制药组合物。本发明还涉及使用式（I）中所表示的化合物治疗与钙感受受体功能相关的疾病或障碍的方法。其中Cy1为吡啶基、吡啶基、喹啉基或9-乙基-9H-β-咔唑基，每种基团均可选择性地取代，Cy2为苯基萘基。
• US8791147B2
  申请人：——

  公开号：US8791147B2

  公开（公告）日：2014-07-29
• [EN] CALCIUM RECEPTOR MODULATING AGENTS<br/>[FR] AGENTS MODULATEURS DES RÉCEPTEURS DE CALCIUM
  申请人：AMGEN INC

  公开号：WO2010042642A1

  公开（公告）日：2010-04-15

  The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.