2-n-Pentyltetrahydropyran-γ-pyron | 23659-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-n-Pentyltetrahydropyran-γ-pyron
• 英文别名: 2-Pentyloxan-4-one
• CAS: 23659-47-4
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: FJOUCLXTCWFRQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正己醛 、 3-(phenylthio)but-3-en-1-ol 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以65%的产率得到2-n-Pentyltetrahydropyran-γ-pyron
  参考文献：
  名称：

  四氢吡喃-4-酮衍生物的合成及其在Fisher吲哚合成中的行为的新的自封端Prins策略†

  摘要：

  已开发出一种新颖的自封端Prins策略，用于在5 mol存在下通过3-（苯硫基）but-3-en-1-醇与羰基化合物的缩合反应合成2-取代的四氢吡喃-4-酮衍生物。在温和条件下的Sc（OTf）3的百分比。随后通过费希尔-吲哚合成将一些产物转化为相应的吲哚。

  DOI：

  10.1039/c6ra11218h

文献信息

• REDUCTION OF THE TOXIC EFFECT OF IMPURITIES FROM RAW MATERIALS BY EXTRACTIVE FERMENTATION
  申请人：Bhatia Monica

  公开号：US20090084025A1

  公开（公告）日：2009-04-02

  There are provided bioproducts and methods of improving production of the bioproducts from engineered microbial cells, the methods comprising: providing a fermentation broth comprising a crude carbon source; inoculating said fermentation broth with said microbial cells; and incubating the inoculated fermentation broth; wherein said bioproduct is a hydrophobic solvent immiscible with said fermentation broth, and wherein a toxic side product present in said crude carbon source is soluble in said hydrophobic solvent. Also, provided are kits for practicing the methods of improving production of bioproducts.
• US8313934B2
  申请人：——

  公开号：US8313934B2

  公开（公告）日：2012-11-20
• [EN] REDUCTION OF THE TOXIC EFFECT OF IMPURITIES FROM RAW MATERIALS BY EXTRACTIVE FERMENTATION<br/>[FR] DIMINUTION DE L'EFFET TOXIQUE D'IMPURETÉS PROVENANT DE MATIÈRES BRUTES PAR UNE FERMENTATION EXTRACTIVE
  申请人：LS9 INC

  公开号：WO2009042950A1

  公开（公告）日：2009-04-02

  There are provided bioproducts and methods of improving production of the bioproducts from engineered microbial cells, the methods comprising: providing a fermentation broth comprising a crude carbon source; inoculating said fermentation broth with said microbial cells; and incubating the inoculated fermentation broth; wherein said bioproduct is a hydrophobic solvent immiscible with said fermentation broth, and wherein a toxic side product present in said crude carbon source is soluble in said hydrophobic solvent. Also, provided are kits for practicing the methods of improving production of bioproducts.
• A novel self-terminated Prins strategy for the synthesis of tetrahydropyran-4-one derivatives and their behaviour in Fisher indole synthesis
  作者：B. V. Subba Reddy、S. Rehana Anjum、B. Sridhar

  DOI：10.1039/c6ra11218h

  日期：——

  has been developed for the synthesis of 2-substituted tetrahydropyran-4-one derivatives through a condensation of 3-(phenylthio)but-3-en-1-ol with carbonyl compounds in the presence of 5 mol% of Sc(OTf)3 under mild conditions. A few products were subsequently transformed into the corresponding indoles by Fisher-indole synthesis.

  已开发出一种新颖的自封端Prins策略，用于在5 mol存在下通过3-（苯硫基）but-3-en-1-醇与羰基化合物的缩合反应合成2-取代的四氢吡喃-4-酮衍生物。在温和条件下的Sc（OTf）3的百分比。随后通过费希尔-吲哚合成将一些产物转化为相应的吲哚。