8-(6-amino-5-trifluoromethyl-pyridin-3-yl)-1-(6-methoxy-2-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one | 1257429-78-9

• 英文名称: 8-(6-amino-5-trifluoromethyl-pyridin-3-yl)-1-(6-methoxy-2-methyl-pyridin-3-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one
• 英文别名: 8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1-(6-methoxy-2-methylpyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one；8-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-1-(6-methoxy-2-methylpyridin-3-yl)-3-methylimidazo[4,5-c]quinolin-2-one
• CAS: 1257429-78-9
• 化学式: C₂₄H₁₉F₃N₆O₂
• 分子量: 480.449
• InChiKey: JELJSGMPCBHNGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  97.5
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] COMPOSÉS 1H-IMIDAZO [4,5-C] QUINOLINONE UTILES POUR LE TRAITEMENT DES MALADIES PROLIFÉRATIVES
  申请人：NOVARTIS AG

  公开号：WO2010139747A1

  公开（公告）日：2010-12-09

  The invention relates to the use of 1 H-imidazo[4,5-c]quinolinone compounds and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1 H-imidazo[4,5-c]quinolinone compounds for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1 H-imidazo[4,5-c]quinolinone compounds to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1 H-imidazo[4,5-c]quinolinone compounds, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1 H-imidazo[4,5-c]quinolinone compounds; and a process for the preparation of the novel 1 H-imidazo[4,5-c]quinolinone compounds.

  该发明涉及在蛋白质和/或脂质激酶依赖性疾病的治疗中使用1 H-咪唑[4,5-c]喹啉酮化合物及其盐，并用于制备用于治疗该疾病的药物制剂；1 H-咪唑[4,5-c]喹啉酮化合物用于治疗蛋白质和/或脂质激酶依赖性疾病；一种治疗上述疾病的方法，包括向温血动物，特别是人类，给予1 H-咪唑[4,5-c]喹啉酮化合物；包含1 H-咪唑[4,5-c]喹啉酮化合物的药物制剂，特别用于治疗蛋白质和/或脂质激酶依赖性疾病；新型1 H-咪唑[4,5-c]喹啉酮化合物；以及制备新型1 H-咪唑[4,5-c]喹啉酮化合物的方法。
• [EN] SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOQUINOLINE SUBSTITUÉS
  申请人：PIRAMAL LIFE SCIENCES LTD

  公开号：WO2012077031A1

  公开（公告）日：2012-06-14

  The present invention relates to substituted imidazo[4,5-c]quinoline derivatives of formula (I), wherein R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of the present invention and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammation and angiogenesis related disorders.

  本发明涉及公式（I）中的取代咪唑并[4,5-c]喹啉衍生物，其中R1、R2和R3如规范中定义，其制备方法，包括本发明化合物的药物组合物，以及它们在治疗由一个或多个激酶介导的疾病或紊乱中的用途，特别是增殖性疾病或紊乱，如癌症。这些化合物也可用于治疗与炎症和血管生成相关的紊乱。
• Substituted Imidazoquinoline Derivatives
  申请人：Kumar Sanjay

  公开号：US20130310374A1

  公开（公告）日：2013-11-21

  The present invention relates to substituted imidazo[4,5-c]quinoline derivatives of formula (I), wherein R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of the present invention and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammation and angiogenesis related disorders.

  本发明涉及公式(I)的取代的咪唑[4,5-c]喹啉衍生物，其中R1、R2和R3如规范中所定义，其制备过程，包含本发明化合物的药物组合物以及它们在治疗由一个或多个激酶介导的疾病或障碍，特别是增殖性疾病或障碍，如癌症中的用途。这些化合物也可以用于治疗与炎症和血管生成相关的疾病或障碍。
• 1H-IMIDAZO[4,5-c]QUINOLINONE COMPOUNDS
  申请人：Furet Pascal

  公开号：US20100311714A1

  公开（公告）日：2010-12-09

  The invention relates to the use of 1H-imidazo[4,5-c]quinolinone compounds and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone compounds for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone compounds to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone compounds, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone compounds; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone compounds.

  本发明涉及使用1H-咪唑[4,5-c]喹啉酮化合物及其盐在治疗蛋白质和/或脂质激酶依赖性疾病方面的应用，以及用于制造治疗该类疾病的药物制剂；使用1H-咪唑[4,5-c]喹啉酮化合物治疗蛋白质和/或脂质激酶依赖性疾病的方法；通过向温血动物，特别是人类，给予1H-咪唑[4,5-c]喹啉酮化合物来治疗上述疾病的方法；包含1H-咪唑[4,5-c]喹啉酮化合物的药物制剂，特别是用于治疗蛋白质和/或脂质激酶依赖性疾病的制剂；新型1H-咪唑[4,5-c]喹啉酮化合物；以及制备新型1H-咪唑[4,5-c]喹啉酮化合物的方法。
• 1H-IMIDAZO[4,5-C]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：Novartis AG

  公开号：EP2438063A1

  公开（公告）日：2012-04-11