2-cyano-4'-({(1R,2S)-2[(isopropylsulfonyl)amino]cyclopentyl}oxy)biphenyl-4-carboxylic acid | 1258963-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-cyano-4'-({(1R,2S)-2[(isopropylsulfonyl)amino]cyclopentyl}oxy)biphenyl-4-carboxylic acid
• 英文别名: 3-cyano-4-[4-[(1R,2S)-2-(propan-2-ylsulfonylamino)cyclopentyl]oxyphenyl]benzoic acid
• CAS: 1258963-88-0
• 化学式: C₂₂H₂₄N₂O₅S
• 分子量: 428.509
• InChiKey: SFWHJHMLNMIXKG-LEWJYISDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] SULFONAMIDES HÉTÉROCYCLIQUES, UTILISATIONS ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
  申请人：PFIZER

  公开号：WO2010150192A1

  公开（公告）日：2010-12-29

  The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I) as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

  该发明涉及一类化合物，包括该化合物的药用可接受盐，其具有规范中定义的式(I)的结构。该发明还涉及含有和使用式I化合物的组合物。
• Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof
  申请人：Fliri Anton F. J.

  公开号：US20110105533A1

  公开（公告）日：2011-05-05

  The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

  本发明涉及一类化合物，包括化合物的药用可接受盐，其结构如式I所定义。本发明还涉及含有式I化合物的组合物和其用途。
• HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Fliri Anton F. J.

  公开号：US20120322823A1

  公开（公告）日：2012-12-20

  The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

  本发明涉及一类化合物，包括化合物的药学上可接受的盐，其结构如公式I所定义。本发明还涉及含有公式I化合物的组合物和其用途。
• US8278457B2
  申请人：——

  公开号：US8278457B2

  公开（公告）日：2012-10-02