8-[6-(dimethylamino)pyridin-3-yl]-1-(1-glycoloylpiperidin-4-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one | 1220699-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 8-[6-(dimethylamino)pyridin-3-yl]-1-(1-glycoloylpiperidin-4-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
• 英文别名: 8-[6-(Dimethylamino)-3-pyridinyl]-1,3-dihydro-1-[1-(2-hydroxyacetyl)-4-piperidinyl]-3-methyl-2H-imidazo[4,5-c][1,5]naphthyridin-2-one；8-[6-(dimethylamino)pyridin-3-yl]-1-[1-(2-hydroxyacetyl)piperidin-4-yl]-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one
• CAS: 1220699-07-9
• 化学式: C₂₄H₂₇N₇O₃
• 分子量: 461.523
• InChiKey: XQLUKUIXLCBLHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS<br/>[FR] COMPOSÉS D'IMIDAZO[1,5]NAPHTYRIDINE, LEUR UTILISATION PHARMACEUTIQUE ET COMPOSITIONS ASSOCIÉES
  申请人：PFIZER

  公开号：WO2010038165A1

  公开（公告）日：2010-04-08

  The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-Kα inhibitors and/or PI3- Kα/mTOR dual inhibitors.

  本发明涉及式(I)的化合物，以及其盐、它们的合成以及它们作为PI3-Kα抑制剂和/或PI3-Kα/mTOR双重抑制剂的用途。
• IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS
  申请人：Cheng Hengmiao

  公开号：US20110190326A1

  公开（公告）日：2011-08-04

  The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-Kα inhibitors and/or PI3-Kα/mTOR dual inhibitors.

  本发明涉及式(I)化合物及其盐、它们的合成以及它们作为PI3-Kα抑制剂和/或PI3-Kα/mTOR双重抑制剂的用途。
• US8791131B2
  申请人：——

  公开号：US8791131B2

  公开（公告）日：2014-07-29