The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I)
1
wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R
1
and R
2
are notably independently hydrogen, alkyl or cycloalkyl and &OHgr; is —NR
46
R
47
or —OR
48
R
46
and R
47
are notably independently hydrogen, alkyl, cycloalkyl or —(CH
2
)
k
—COOR
51
, R
51
is notably alkyl or haloalkyl and R
48
is notably hydrogen or alkyl.
These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
本发明涉及
噻唑、
噁唑、
咪唑、
异噁唑和
异噁唑啉的一般式(I)衍
生物,其中Het为
噻唑、
噁唑、
咪唑、
异噁唑或
异噁唑啉,n为0至6的整数,A特别选自各种可任选取代的芳香族基团,B特别为氢、烷基或苯基,R1和R2特别独立地为氢、烷基或环烷基,Ω为—NR46R47或—OR48,R46和R47特别独立地为氢、烷基、环烷基或—(
CH2)k—COOR51,R51特别为烷基或卤代烷基,R48特别为氢或烷基。这些化合物具有有利的药理学特性,使其可用于治疗学,特别是用于治疗神经退行性疾病或疼痛。