1-benzyl-2-((4S,4R',5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxalan)-5-yl)-1,2,3,6-tetrahydropyridine | 1268685-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-2-((4S,4R',5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxalan)-5-yl)-1,2,3,6-tetrahydropyridine
• CAS: 1268685-28-4
• 化学式: C₂₂H₃₁NO₄
• 分子量: 373.492
• InChiKey: WHTDBKHZLSEPCG-PDZGYPDUSA-N

反应信息

• 作为产物：
  描述：

  N-allyl-N-benzyl-1-((4S,4R',5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxalan)-5-yl)but-3-en-1-amine 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以85%的产率得到1-benzyl-2-((4S,4R',5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxalan)-5-yl)-1,2,3,6-tetrahydropyridine
  参考文献：
  名称：

  An improved method of ring closing metathesis in the presence of basic amines: application to the formal synthesis of (+)-lentiginosine and other piperidines and carbamino sugar analogs

  摘要：

  A generalized method for performing ring closing metathesis in the presence of basic amines has been established and successfully used in the formal synthesis of (+)-lentiginosine as well as some valuable intermediates for the synthesis of several other azasugars and aminocyclitols. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.12.020