[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-dimethyl-N-[(2-(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy-1,2-diphenylethoxy)ethyl]amine | 870298-19-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-dimethyl-N-[(2-(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy-1,2-diphenylethoxy)ethyl]amine
• CAS: 870298-19-4
• 化学式: C₃₀H₄₁NO₃
• 分子量: 463.66
• InChiKey: ADYGBFNLXRRWHJ-FCWFWGBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.25
• 重原子数：
  34.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  30.93
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-dimethyl-N-[(2-(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy-1,2-diphenylethoxy)ethyl]amine 在 4-二甲氨基吡啶 、 N,N-二甲氨基-2-氯丙烷盐酸盐 、 L-Selectride 、 对甲苯磺酸 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (R)-hydroxy-phenylacetic acid (1R,2S)-2-(2-dimethylaminoethoxy)-1,2-diphenylethyl ester
  参考文献：
  名称：

  Chiral linker. Part 2: Synthesis and evaluation of a novel, reusable solid-supported open chain chiral auxiliary derived from m-hydrobenzoin for the diastereoselective reduction of α-keto esters

  摘要：

  Three novel m-hydrobenzoin derived chiral hydrobenzoin mono-alkyl ethers were synthesized and evaluated as open chain chiral auxiliaries in the L-selectride(R)/ZnCl2 mediated stereoselective reduction of their corresponding phenyl glyoxylates, resulting in des of up to 91%. The optimized auxiliary structure was immobilized on commercially available Wang-resin by using the ether substituent as a sublinking unit and applied as a reusable solid-supported chiral auxiliary in the same type of reaction with only little loss of stereofacial selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.030
• 作为产物：
  描述：

  [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethanol 、 2-氯-N,N-二甲基乙胺 在 sodium hydride 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以32%的产率得到[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-dimethyl-N-[(2-(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy-1,2-diphenylethoxy)ethyl]amine
  参考文献：
  名称：

  Chiral linker. Part 2: Synthesis and evaluation of a novel, reusable solid-supported open chain chiral auxiliary derived from m-hydrobenzoin for the diastereoselective reduction of α-keto esters

  摘要：

  Three novel m-hydrobenzoin derived chiral hydrobenzoin mono-alkyl ethers were synthesized and evaluated as open chain chiral auxiliaries in the L-selectride(R)/ZnCl2 mediated stereoselective reduction of their corresponding phenyl glyoxylates, resulting in des of up to 91%. The optimized auxiliary structure was immobilized on commercially available Wang-resin by using the ether substituent as a sublinking unit and applied as a reusable solid-supported chiral auxiliary in the same type of reaction with only little loss of stereofacial selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.030