(1S,2S,3R,4R)-3-(6-chloro-2-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-ylamino)-N-(2-hydroxyethyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide | 1449504-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1S,2S,3R,4R)-3-(6-chloro-2-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-ylamino)-N-(2-hydroxyethyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide
• 英文别名: (1S,2S,3R,4R)-3-(6-Chloro-2-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-ylamino)-N-(2-hydroxyethyl)bicyclo[2.2.1]hept-5-en-2-carboxamide；(1S,2S,3R,4R)-3-[[6-chloro-2-(1-methylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]-N-(2-hydroxyethyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide
• CAS: 1449504-35-1
• 化学式: C₂₀H₂₂ClN₇O₂
• 分子量: 427.893
• InChiKey: QOKYSGRAJBWFRK-FDRIWYBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders
  申请人：Cephalon, Inc.

  公开号：US20140350011A1

  公开（公告）日：2014-11-27

  This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

  本申请涉及公式I所定义的化合物和/或其盐。本申请还涉及使用这些化合物和/或其盐的组合物和方法。公式I的化合物可用作ALK和JAK调节剂，用于治疗增生性疾病。
• IMIDAZO [4, 5 - B]PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：Cephalon, Inc.

  公开号：EP2809671B1

  公开（公告）日：2016-01-13
• US9238656B2
  申请人：——

  公开号：US9238656B2

  公开（公告）日：2016-01-19