2-ethyl-4-oxo-4H-pyran-3-yl 4-hydroxy-3-methoxybenzoate | 2088247-61-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethyl-4-oxo-4H-pyran-3-yl 4-hydroxy-3-methoxybenzoate
• 英文别名: 2-ethyl-4-oxo-4H-pyran-3-yl-ester-4-hydroxy-3-methoxy-benzoic acid；(2-ethyl-4-oxopyran-3-yl) 4-hydroxy-3-methoxybenzoate
• CAS: 2088247-61-2
• 化学式: C₁₅H₁₄O₆
• 分子量: 290.273
• InChiKey: NHGPHSDMEIUFCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  香草酸 在 五氯化磷 、 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 5.0h， 生成 2-ethyl-4-oxo-4H-pyran-3-yl 4-hydroxy-3-methoxybenzoate
  参考文献：
  名称：

  EP3345910

  摘要：

  公开号：

文献信息

• COMPOUND HAVING EFFECT OF INHIBITING PLATELET AGGREGATION AND SALT THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING THROMBOTIC DISEASES, CONTAINING SAME
  申请人：Shin Poong Pharmaceutical Co., Ltd.

  公开号：EP3345910A1

  公开（公告）日：2018-07-11

  The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel platelet aggregation inhibitor specifically inhibiting shear stress-induced platelet aggregation; a pharmaceutical composition containing the same as an active ingredient; and a preparation method therefor.

  本发明涉及一种具有抑制血小板聚集作用的新型化合物及其盐，更具体地说，涉及：一种新型血小板聚集抑制剂，专门抑制剪切应力诱导的血小板聚集；一种药物组合物，其活性成分中含有该化合物；及其制备方法。
• Compound having effect of inhibiting platelet aggregation and salt thereof, and composition for preventing or treating thrombotic diseases, containing same
  申请人：SHIN POONG PHARMACEUTICAL CO., LTD.

  公开号：US10730886B2

  公开（公告）日：2020-08-04

  The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel platelet aggregation inhibitor specifically inhibiting shear stress-induced platelet aggregation; a pharmaceutical composition containing the same as an active ingredient; and a preparation method therefor.

  本发明涉及一种具有抑制血小板聚集作用的新型化合物及其盐，更具体地说，涉及：一种新型血小板聚集抑制剂，专门抑制剪切应力诱导的血小板聚集；一种药物组合物，其活性成分中含有该化合物；及其制备方法。
• Compound Having Effect Of Inhibiting Platelet Aggregation And Salt Thereof, And Composition For Preventing Or Treating Thrombotic Diseases, Containing Same
  申请人：SHIN POONG PHARMACEUTICAL CO., LTD.

  公开号：US20180251472A1

  公开（公告）日：2018-09-06

  The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel platelet aggregation inhibitor specifically inhibiting shear stress-induced platelet aggregation; a pharmaceutical composition containing the same as an active ingredient; and a preparation method therefor.
• [EN] COMPOUND HAVING EFFECT OF INHIBITING PLATELET AGGREGATION AND SALT THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING THROMBOTIC DISEASES, CONTAINING SAME<br/>[FR] COMPOSÉ AYANT POUR EFFET D'INHIBER L'AGRÉGATION PLAQUETTAIRE, SEL DE CELUI-CI, ET COMPOSITION DESTINÉE À PRÉVENIR OU À TRAITER LES MALADIES THROMBOTIQUES LE CONTENANT<br/>[KO] 혈소판 응집 저해 효과를 갖는 화합물 및 그 염, 그리고 이를 포함하는 혈전성 질환 예방 또는 치료용 조성물
  申请人：SHIN POONG PHARMACEUTICAL CO LTD

  公开号：WO2017039395A1

  公开（公告）日：2017-03-09

  본 발명은 혈소판 응집 저해 효과를 갖는 신규한 화합물 및 그 염류에 관한 것으로서, 더욱 상세하게는 전단응력에 의한 혈소판 응집(shear stress-induced platelet aggregation)을 선택적으로 저해하는 새로운 혈소판 응집 저해제 및 이를 유효성분으로 하는 약학적 조성물 및 그 제조 방법에 관한 것이다.