4-[(1S)-1-pyrrolidin-1-ylethyl]aniline | 1093095-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(1S)-1-pyrrolidin-1-ylethyl]aniline
• CAS: 1093095-08-9
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.288
• InChiKey: VTHAYHQWOGVFFL-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INDOLINE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER
  申请人：Treu Matthias

  公开号：US20100184747A1

  公开（公告）日：2010-07-22

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 4 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
• [EN] INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER<br/>[FR] DÉRIVÉS D'INDOLINONE ET LEUR UTILISATION DANS LE TRAITEMENT D'ÉTATS PATHOLOGIQUES TELS QUE LE CANCER
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2008152013A1

  公开（公告）日：2008-12-18

  [EN] The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
  [FR] La présente invention concerne des composés de formule générale (1), les R1 à R4 étant définis tels que dans la revendication 1, qui sont appropriés pour traiter des maladies caractérisées par une prolifération cellulaire excessive ou anormale, et leur utilisation pour préparer une composition pharmaceutique ayant les propriétés mentionnées ci-dessus.