3-Chloro-2[-(1-methyl-1H-imidazol-2yl)thio]benzenamine | 133303-63-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Chloro-2[-(1-methyl-1H-imidazol-2yl)thio]benzenamine
• 英文别名: 3-Chloro-2-(1-methylimidazol-2-yl)sulfanylaniline
• CAS: 133303-63-6
• 化学式: C₁₀H₁₀ClN₃S
• 分子量: 239.728
• InChiKey: CDMRMUBDNUEANY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  69.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
  申请人：Berger Maarten Dan

  公开号：US20060041127A1

  公开（公告）日：2006-02-23

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  本发明涉及一种4,6,7,8-取代苯并[g]喹啉-3-羧腈和4,6,7,8-取代苯并[g]喹唑啉的区域选择性合成方法及其中间体。本发明所得化合物可用于治疗多种疾病，这些疾病是由这些PTK的失调所致，更具体地说，它们是抗癌剂，可用于治疗哺乳动物的癌症。此外，本发明所得化合物还可用于治疗哺乳动物的多囊肾病。
• METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES
  申请人：Berger Dan Maarten

  公开号：US20080171874A1

  公开（公告）日：2008-07-17

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  本发明涉及一种4,6,7,8-取代苯并[g]喹啉-3-碳腈和4,6,7,8-取代苯并[g]喹唑啉的区域选择性合成方法，以及它们的中间体。本发明得到的化合物可用于治疗多种由这些PTK的失调引起的疾病，更具体地说，是抗癌剂，可用于治疗哺乳动物的癌症。此外，本发明得到的化合物还可用于治疗哺乳动物的多囊肾病。
• US4973599A
  申请人：——

  公开号：US4973599A

  公开（公告）日：1990-11-27