1,4,7-triisopropyl-1,4,7-triazaheptane | 10524-50-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4,7-triisopropyl-1,4,7-triazaheptane
• 英文别名: N,N',N''-triisopropyldiethylenetriamine；1,4,7-Triisopropyl-diaethylentriamin；1,4,7-Triisopropyl-diethylentriamin；isopropyl-bis-(2-isopropylamino-ethyl)-amine；N,N'-di(propan-2-yl)-N'-[2-(propan-2-ylamino)ethyl]ethane-1,2-diamine
• CAS: 10524-50-2
• 化学式: C₁₃H₃₁N₃
• 分子量: 229.409
• InChiKey: FEPITLKPHDBIIL-UHFFFAOYSA-N

物化性质

• 沸点：
  123-124 °C(Press: 14 Torr)
• 密度：
  0.852±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二(二甲氨基)二甲基硅 、 1,4,7-triisopropyl-1,4,7-triazaheptane 在 氯化铵 作用下， 生成 1,3,6-triisopropyl-2,2-dimethyl-[1,3,6,2]triazasilocane
  参考文献：
  名称：

  Gol'din,G.S. et al., Journal of general chemistry of the USSR, 1972, vol. 42, p. 1033 - 1036

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2’-[(1-甲基乙基)亚氨基]二乙醇 在 氯化亚砜 作用下， 生成 1,4,7-triisopropyl-1,4,7-triazaheptane
  参考文献：
  名称：

  Gelbard,G.; Rumpf,P., Bulletin de la Societe Chimique de France, 1969, p. 1161 - 1170

  摘要：

  DOI：

文献信息

• [EN] AMINE COMPOSITION USEFUL FOR MAKING STABLE POLYURETHANE FOAM SYSTEMS<br/>[FR] COMPOSITION D'AMINE UTILE DANS LA FABRICATION DE SYSTÈMES DE MOUSSE DE POLYURÉTHANE STABLE
  申请人：EVONIK OPERATIONS GMBH

  公开号：WO2020174030A1

  公开（公告）日：2020-09-03

  Acatalyst composition comprising at least one compound with a general formula (I) wherein A is N-R3, R3 is C1-C8 linear or branched, x = 0-6, n and m are each independently 1 to 6, R1 and R2 are each independently C2 -C8 alkyl, and R4 and R5 are -CH3 groups; or A = O, x = 0-6, n and m are each independently 1 to 6, R1 and R 2 are each independently C2-C8 alkyl, and R4 and R5 are -CH3 groups; or A = O or N-R3, R3 is C1-C8 linear or branched, and N(R1---R4) and N(R2---R5) each independently represent a C3-C7 ring amine moiety of the type: (II).

  一种催化剂组合物，包括至少一种具有通式(I)的化合物，其中A为N-R3，R3为C1-C8线性或支链，x=0-6，n和m分别独立取1至6，R1和R2分别独立为C2-C8烷基，R4和R5为-CH3基团；或A=O，x=0-6，n和m分别独立取1至6，R1和R2分别独立为C2-C8烷基，R4和R5为- 基团；或A=O或N-R3，R3为C1-C8线性或支链，N(R1---R4)和N(R2---R5)分别独立表示类型为(II)的C3-C7环胺基团。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。
• Multifunctionalized polyethylene glycol derivative and preparation method therefor
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US11324827B2

  公开（公告）日：2022-05-10

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n1, n2, n3, and n4 respectively are the degrees of polymerization of the branch chains, U1 and U2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F1 and F2 contain a functional group or a protected form R01 thereof and may or may not contain a branched group G, correspondingly, the number of R01 is one or more, F1 and F2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.

  本发明公开了一种多功能聚乙二醇衍生物及其制备方法。该衍生物具有由式（1）表示的 H 型结构，包括一个线性核心 LPEG 和四个 PEG 支链，其中 n1、n2、n3 和 n4 分别为支链的聚合度，U1 和 U2 为连接核心 LPEG 和两个 PEG 支链的三价支化基团、F1 和 F2 含有一个官能团或其保护形式 R01，可以含有或不含有支链基团 G，相应地，R01 的数目为一个或多个，F1 和 F2 要么相同要么不同，分子中的任何一个连接基团或与相邻杂原子基团形成的任何连接基团要么保持稳定，要么降解，分子中的任何一个 PEG 段离散多分散或单分散。多功能聚乙二醇的支链结构和支臂长度灵活多样，各种参数和性能指标可调且易于控制，具有广泛的适用性。
• Reaction of 1,2-dibromoethane with primary amines: formation of N , N ′-disubstituted ethylenediamines RNH–CH 2 CH 2 –NHR and homologous polyamines RNH–[CH 2 CH 2 NR] n –H
  作者：Michael K Denk、Mike J Krause、Debyani F Niyogi、Nachhattarpal K Gill

  DOI：10.1016/s0040-4020(03)01149-9

  日期：2003.9

  The reaction of primary amines RNH2 (R: Me, Et, iPr, tBu and Ph) with 1,2-dibromoethane gave N,N'-disubstituted ethylenediamines R-NH-CH2CH2-NH-R (1) in yields ranging from 10% (1a; R=Me) to 70% (1d, R=tBu; 1e, R=Ph). Piperazines and N-substituted polyethyleneimines were identified (H-1 NMR, C-13 NMR and EI-MS) as side products of the reaction and isolated by fractional distillation. The piperazines 2 are formed in yields of 3-10% and can be separated from the diamines 1 in all cases, except for R=Me and Ph. The polyamine homologues RNH-[CH2CH2NR](n)-H (3-5) were isolated in yields ranging from 0.1% (n=4, R=iPr) to 14% (n=2, R=iPr). The yields of 1 increase with the size of the substituent R, no obvious trend exists for the yields of the side products. (C) 2003 Elsevier Ltd. All rights reserved.
• Gelbard,G.; Rumpf,P., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1966, vol. 262, p. 1587 - 1590
  作者：Gelbard,G.、Rumpf,P.

  DOI：——

  日期：——