4-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-d]pyrimidin-2-amine | 1132688-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡嗪类
• 英文名称: 4-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-d]pyrimidin-2-amine
• 英文别名: 4-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-6,7,8,9-tetrahydro-[1]benzothiolo[3,2-d]pyrimidin-2-amine
• CAS: 1132688-51-7
• 化学式: C₁₅H₁₇N₇S
• 分子量: 327.413
• InChiKey: KCVQNAIYRLUPHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Thieno-and furo-pyrimidine modulators of the histamine H4 receptor
  申请人：Edwards James P.

  公开号：US20090075970A1

  公开（公告）日：2009-03-19

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  描述了噻吩-和呋喃-嘧啶化合物，这些化合物可用作H4受体调节剂。这些化合物可以用于制药组合物和用于调节组胺H4受体活性以及治疗由H4受体活性介导的疾病状态、紊乱和条件的方法，如炎症。
• Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders
  申请人：Desmadryl Gilles

  公开号：US20120039913A1

  公开（公告）日：2012-02-16

  The invention relates to Histamine H4 receptor antagonists or inhibitors of Histamine H4 receptor gene expression for the treatment and/or the prevention of vestibular disorders.

  该发明涉及组胺H4受体拮抗剂或组胺H4受体基因表达抑制剂，用于治疗和/或预防前庭障碍。
• THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120270855A1

  公开（公告）日：2012-10-25

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了一种噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可用于制备药物组合物和方法，用于调节组胺H4受体活性和治疗由H4受体活性介导的疾病状态、障碍和病况，如炎症。
• THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120214792A1

  公开（公告）日：2012-08-23

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可用于制备药物组合物和方法，以调节组胺H4受体活性，并用于治疗由H4受体活性介导的疾病状态、障碍和病情，例如炎症。
• H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS
  申请人：Sensorion

  公开号：EP3378476A1

  公开（公告）日：2018-09-26

  The invention relates to Histamine type 4 receptor (H4R) inhibitors for treating tinnitus.

  本发明涉及用于治疗耳鸣的组胺 4 型受体（H4R）抑制剂。