2(1H)-Pyridinone,1-[4-(methylthio)phenyl]-5-(trifluoromethyl)- | 1198411-43-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2(1H)-Pyridinone,1-[4-(methylthio)phenyl]-5-(trifluoromethyl)-
• 英文别名: 1-(4-methylsulfanylphenyl)-5-(trifluoromethyl)pyridin-2-one
• CAS: 1198411-43-6
• 化学式: C₁₃H₁₀F₃NOS
• 分子量: 285.29
• InChiKey: HEQPPMRIJHQQEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
  申请人：Kossen Karl

  公开号：US20090318455A1

  公开（公告）日：2009-12-24

  Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

  公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物对p38 MAPK的抑制效力较低；并且其中接触是在SAPK调节浓度下进行的，该浓度对化合物抑制p38 MAPK的抑制浓度百分比较低。还公开了吡非尼酮的衍生物和类似物，它们可用于调节应激活化蛋白激酶（SAPK）系统。
• METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS
  申请人：Olgin Jeff

  公开号：US20100190731A1

  公开（公告）日：2010-07-29

  The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• Methods for Treating Acute Myocardial Infarctions and Associated Disorders
  申请人：Olgin Jeff

  公开号：US20110218515A1

  公开（公告）日：2011-09-08

  The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS
  申请人：Kossen Karl

  公开号：US20120014917A1

  公开（公告）日：2012-01-19

  The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• US8304413B2
  申请人：——

  公开号：US8304413B2

  公开（公告）日：2012-11-06