1-benzyl-2,6-dioxo-N-((3'-sulfamoyl-3-(trifluoromethoxy)biphenyl-4-yl)methyl)-1,2,3,6-tetrahydropyrimidine-4-carboxamide | 1254837-68-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-2,6-dioxo-N-((3'-sulfamoyl-3-(trifluoromethoxy)biphenyl-4-yl)methyl)-1,2,3,6-tetrahydropyrimidine-4-carboxamide
• 英文别名: 3-benzyl-2,4-dioxo-N-[[4-(3-sulfamoylphenyl)-2-(trifluoromethoxy)phenyl]methyl]-1H-pyrimidine-6-carboxamide
• CAS: 1254837-68-7
• 化学式: C₂₆H₂₁F₃N₄O₆S
• 分子量: 574.537
• InChiKey: LMHGPWJOEAPECO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  156
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES<br/>[FR] 2,6-DIOXO-1, 2, 3, 6-TÉTRAHYDROPYRIMIDINE-4-CARBOXAMIDES
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2010129848A2

  公开（公告）日：2010-11-11

  Disclosed are sEH inhibitors of formula (I), wherein the variables are as defined herein, as well as pharmaceutical compositions, kits, and articles of manufacture that contain such compounds. Also disclosed are methods and intermediates for making the compounds and the use of such compounds to treat various disorders, diseases, and conditions associated with sEH.